Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation

Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is co...

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Veröffentlicht in:	Molecular cell 2006-05, Vol.22 (3), p.317-327
Hauptverfasser:	Liu, Xuan, Huang, Wei, Li, Chufang, Li, Ping, Yuan, Jing, Li, Xiaorong, Qiu, Xiao-Bo, Ma, Qingjun, Cao, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - physiology CELLCYCLE Cells, Cultured Cysteine Endopeptidases - metabolism Gene Expression Regulation Humans K562 Cells Mice Models, Biological Oxidative Stress Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Processing, Post-Translational Protein-Tyrosine Kinases - metabolism PROTEINS Proto-Oncogene Proteins c-abl - metabolism Radiation, Ionizing
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