Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation
Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is co...
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| Veröffentlicht in: | Molecular cell 2006-05, Vol.22 (3), p.317-327 |
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| container_issue | 3 |
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| container_title | Molecular cell |
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| creator | Liu, Xuan Huang, Wei Li, Chufang Li, Ping Yuan, Jing Li, Xiaorong Qiu, Xiao-Bo Ma, Qingjun Cao, Cheng |
| description | Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control. |
| doi_str_mv | 10.1016/j.molcel.2006.04.007 |
| format | Article |
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The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. 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The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (α4) subunit at Tyr-153. Consequently, proteasome-dependent proteolysis is compromised. Notably, cells expressing a phosphorylation mutant of PSMA7(Y153F) display impaired G1/S transition and S/G2 progression, highlighting the biological significance of tyrosine phosphorylation of a proteasome subunit as an important cellular regulatory control.</description><subject>Animals</subject><subject>Cell Cycle - physiology</subject><subject>CELLCYCLE</subject><subject>Cells, Cultured</subject><subject>Cysteine Endopeptidases - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>K562 Cells</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Oxidative Stress</subject><subject>Phosphorylation</subject><subject>Proteasome Endopeptidase Complex - metabolism</subject><subject>Protein Binding</subject><subject>Protein Processing, Post-Translational</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>PROTEINS</subject><subject>Proto-Oncogene Proteins c-abl - metabolism</subject><subject>Radiation, Ionizing</subject><issn>1097-2765</issn><issn>1097-4164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7rr6D0Ry8tZtJZ2P6Ysw7PqxuOLirueQTmqGDN3pMUkr--_NOAN6UihIQZ6qgvch5CWDlgFTb3btNI8Ox5YDqBZEC6AfkXMGvW4EU-LxqedayTPyLOcdABNy1T8lZ0wpvWIgzsn-OhZM1pUwRzpg-YkYqWvWw0ht9HSdtvT-Ic05RKSfQrQZ8--P2zQXtHmekN4twxJDobd3n9eafsXtMtpSsb-QK9wm6-3hyHPyZGPHjC9O7wX59v7d_eXH5ubLh-vL9U3jJHSlkXojtPJKAh_44LkX6HroO9DS8VpWqg1jXILzbmDokKNynHF0zq-08N0FeX3cu0_z9wVzMVPINa7RRpyXbJTuRcek_C_INNMcur6C4gi6mkdOuDH7FCabHgwDc1BiduaoxByUGBCmKqljr077l2FC_2fo5KACb48A1jh-BEwmu4DRoQ8JXTF-Dv--8AtqXJ99</recordid><startdate>20060505</startdate><enddate>20060505</enddate><creator>Liu, Xuan</creator><creator>Huang, Wei</creator><creator>Li, Chufang</creator><creator>Li, Ping</creator><creator>Yuan, Jing</creator><creator>Li, Xiaorong</creator><creator>Qiu, Xiao-Bo</creator><creator>Ma, Qingjun</creator><creator>Cao, Cheng</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060505</creationdate><title>Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation</title><author>Liu, Xuan ; Huang, Wei ; Li, Chufang ; Li, Ping ; Yuan, Jing ; Li, Xiaorong ; Qiu, Xiao-Bo ; Ma, Qingjun ; Cao, Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-57f476d6502b2bd2d4ec9093075c25c2a56f11250cdcb1ece2e6c212eccd874d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Cell Cycle - physiology</topic><topic>CELLCYCLE</topic><topic>Cells, Cultured</topic><topic>Cysteine Endopeptidases - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>K562 Cells</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Oxidative Stress</topic><topic>Phosphorylation</topic><topic>Proteasome Endopeptidase Complex - metabolism</topic><topic>Protein Binding</topic><topic>Protein Processing, Post-Translational</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>PROTEINS</topic><topic>Proto-Oncogene Proteins c-abl - metabolism</topic><topic>Radiation, Ionizing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xuan</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><creatorcontrib>Li, Chufang</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Yuan, Jing</creatorcontrib><creatorcontrib>Li, Xiaorong</creatorcontrib><creatorcontrib>Qiu, Xiao-Bo</creatorcontrib><creatorcontrib>Ma, Qingjun</creatorcontrib><creatorcontrib>Cao, Cheng</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xuan</au><au>Huang, Wei</au><au>Li, Chufang</au><au>Li, Ping</au><au>Yuan, Jing</au><au>Li, Xiaorong</au><au>Qiu, Xiao-Bo</au><au>Ma, Qingjun</au><au>Cao, Cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation</atitle><jtitle>Molecular cell</jtitle><addtitle>Mol Cell</addtitle><date>2006-05-05</date><risdate>2006</risdate><volume>22</volume><issue>3</issue><spage>317</spage><epage>327</epage><pages>317-327</pages><issn>1097-2765</issn><eissn>1097-4164</eissn><abstract>Proteasome-mediated proteolysis is a primary protein degradation pathway in cells. 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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Cell Cycle - physiology CELLCYCLE Cells, Cultured Cysteine Endopeptidases - metabolism Gene Expression Regulation Humans K562 Cells Mice Models, Biological Oxidative Stress Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Processing, Post-Translational Protein-Tyrosine Kinases - metabolism PROTEINS Proto-Oncogene Proteins c-abl - metabolism Radiation, Ionizing |
| title | Interaction between c-Abl and Arg Tyrosine Kinases and Proteasome Subunit PSMA7 Regulates Proteasome Degradation |
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