Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord

Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices. In this study we provide the first evidence that the reeler mutant also has profound sensory defects....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2006, Vol.139 (4), p.1385-1396
Hauptverfasser:	Villeda, S.A., Akopians, A.L., Babayan, A.H., Basbaum, A.I., Phelps, P.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Animals, Newborn Behavior, Animal Biological and medical sciences Cell Adhesion Molecules, Neuronal - deficiency Cell Count - methods Dab1 dorsal horn Embryo, Mammalian Extracellular Matrix Proteins - deficiency Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Humans Immunohistochemistry - methods Male Mice Mice, Neurologic Mutants Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - metabolism neuronal migration NK-1 receptor Pain Measurement - methods Posterior Horn Cells - physiology primary afferents Receptors, Neurokinin-1 - metabolism Receptors, Opioid - physiology reeler Serine Endopeptidases - deficiency Sex Factors Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - cytology Spinal Cord - enzymology Spinal Cord - growth & development Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!