Age-dependent changes of glyoxalase I expression in human brain

Increased modification and crosslinking of proteins by advanced glycation end products (AGEs) is a characteristic feature of aging, and contributes to the formation of many of the lesions of neurodegenerative diseases including neurofibrillary tangles and amyloid plaques in Alzheimer's disease....

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Veröffentlicht in:	Neurobiology of aging 2006-06, Vol.27 (6), p.815-822
Hauptverfasser:	Kuhla, Björn, Boeck, Katharina, Lüth, Hans-Joachim, Schmidt, Angela, Weigle, Bernd, Schmitz, Marc, Ogunlade, Vera, Münch, Gerald, Arendt, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced glycation endproducts Age Factors Aged Aged, 80 and over Aging Aging - metabolism Astrocytes Blotting, Western - methods Cerebral Cortex - cytology Cerebral Cortex - enzymology Female Gene Expression Regulation - physiology Glyoxalase Human brain Humans Immunohistochemistry - methods Lactoylglutathione Lyase - genetics Lactoylglutathione Lyase - metabolism Male Middle Aged Models, Biological Neuroglia - enzymology Neurons Neurons - enzymology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis
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