Ribosome display of mammalian receptor domains

Many mammalian receptor domains, among them a large number of potential therapeutic target proteins, are highly aggregation-prone upon heterologous expression in bacteria. This severely limits functional studies of such receptor domains and also their engineering towards improved properties. One of...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2005-06, Vol.18 (6), p.285-294
Hauptverfasser:	Schimmele, Bernhard, Gräfe, Nico, Plückthun, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circular Dichroism Escherichia coli - genetics GPI-Linked Proteins Growth Inhibitors - genetics Growth Inhibitors - metabolism in vitro evolution Ligands Macaca fascicularis Mutation Myelin Proteins - genetics Myelin Proteins - metabolism Nogo Proteins nogo receptor Nogo Receptor 1 Peptide Library Plasmids protein aggregation Protein Binding Protein Conformation Protein Folding Protein Structure, Tertiary Receptors, Cell Surface Receptors, Peptide - chemistry Receptors, Peptide - genetics Receptors, Peptide - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism ribosome display Ribosomes - metabolism RNA, Transfer, Amino Acyl - metabolism
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