The RXR-Type Endoplasmic Reticulum-Retention/Retrieval Signal of GABAB1 Requires Distant Spacing from the Membrane to Function

Functional γ-aminobutyric acid type B (GABAB) receptors are normally only observed upon coexpression of GABAB1 with GABAB2 subunits. A C-terminal arginine-based endoplasmic reticulum (ER) retention/retrieval signal, RSRR, prevents escape of unassembled GABAB1 subunits from the ER and restricts surfa...

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Veröffentlicht in:	Molecular pharmacology 2005-07, Vol.68 (1), p.137-144
Hauptverfasser:	Gassmann, Martin, Haller, Corinne, Stoll, Yanick, Aziz, Said Abdel, Biermann, Barbara, Mosbacher, Johannes, Kaupmann, Klemens, Bettler, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Membrane - genetics Cell Membrane - physiology Endoplasmic Reticulum - genetics Endoplasmic Reticulum - physiology Humans Receptors, GABA-B - chemistry Receptors, GABA-B - genetics Receptors, GABA-B - physiology Retinoid X Receptors - chemistry Retinoid X Receptors - genetics Retinoid X Receptors - physiology Signal Transduction - physiology
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