Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor
Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides have been found to be antagonists on the human histamine-3-receptor, showing a Ki value of as low as 4 nM.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-06, Vol.16 (12), p.3162-3165 |
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| container_end_page | 3165 |
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| container_issue | 12 |
| container_start_page | 3162 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 16 |
| creator | PESCHKE, Bernd BAK, Sonja HOHLWEG, Rolf NIELSEN, Rita VIUFF, Dorthe RIMVALL, Karin |
| description | Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides have been found to be antagonists on the human histamine-3-receptor, showing a Ki value of as low as 4 nM. |
| doi_str_mv | 10.1016/j.bmcl.2006.03.074 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3162-3165 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67940655 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amides - chemical synthesis Amides - chemistry Amides - pharmacology Benzene - chemistry Biological and medical sciences Furans - chemistry Histamine Antagonists - chemical synthesis Histamine Antagonists - chemistry Histamine Antagonists - pharmacology Humans Medical sciences Miscellaneous Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Receptors, Histamine H3 - metabolism Structure-Activity Relationship Thiophenes - chemistry |
| title | Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor |
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