Novel localization of CD38 in perivascular sympathetic nerve terminals
Using high performance liquid chromatography fraction analysis we have recently established that numerous smooth muscle preparations, including the canine mesenteric artery and vein, release β-nicotinamide adenine dinucleotide upon short-pulse electrical field stimulation in tetrodotoxin- and ω-cono...
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| Veröffentlicht in: | Neuroscience 2006, Vol.139 (4), p.1467-1477 |
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| creator | Smyth, L.M. Breen, L.T. Yamboliev, I.A. Mutafova-Yambolieva, V.N. |
| description | Using high performance liquid chromatography fraction analysis we have recently established that numerous smooth muscle preparations, including the canine mesenteric artery and vein, release β-nicotinamide adenine dinucleotide upon short-pulse electrical field stimulation in tetrodotoxin- and ω-conotoxin GVIA-sensitive manners [
Smyth LM, Bobalova J, Mendoza MG, Lew C, Mutafova-Yambolieva VN (2004) Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem 279:48893–48903.]. The β-nicotinamide adenine dinucleotide metabolites ADP-ribose and cyclic ADP-ribose are also present in the tissue superfusates. CD38 is a multifunctional enzyme involved in the degradation of β-nicotinamide adenine dinucleotide to ADP-ribose and cyclic ADP-ribose. Western immunoblot analysis revealed that CD38 is expressed in both artery and vein. Confocal laser scanning microscopy established colocalization of CD38 with tyrosine hydroxylase, synaptotagmin and synaptic vesicle protein in both blood vessels. High performance liquid chromatography with fluorescence detection demonstrated that whole tissue segments metabolize 1,
N
6-etheno-nicotinamide adenine dinucleotide to 1,
N
6-etheno-ADP-ribose and nicotinamide-guanine dinucleotide to cyclic GDP-ribose, suggesting the presence of both nicotinamide adenine dinucleotide-glycohydrolase and ADP-ribosyl cyclase activities in these blood vessels. Both enzymes appear to be associated with the membrane fraction, and therefore might be attributed to CD38. These data demonstrate a previously uncharacterized localization of CD38 in perivascular autonomic nerve terminals. Therefore, the β-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control. |
| doi_str_mv | 10.1016/j.neuroscience.2006.01.043 |
| format | Article |
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Smyth LM, Bobalova J, Mendoza MG, Lew C, Mutafova-Yambolieva VN (2004) Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem 279:48893–48903.]. The β-nicotinamide adenine dinucleotide metabolites ADP-ribose and cyclic ADP-ribose are also present in the tissue superfusates. CD38 is a multifunctional enzyme involved in the degradation of β-nicotinamide adenine dinucleotide to ADP-ribose and cyclic ADP-ribose. Western immunoblot analysis revealed that CD38 is expressed in both artery and vein. Confocal laser scanning microscopy established colocalization of CD38 with tyrosine hydroxylase, synaptotagmin and synaptic vesicle protein in both blood vessels. High performance liquid chromatography with fluorescence detection demonstrated that whole tissue segments metabolize 1,
N
6-etheno-nicotinamide adenine dinucleotide to 1,
N
6-etheno-ADP-ribose and nicotinamide-guanine dinucleotide to cyclic GDP-ribose, suggesting the presence of both nicotinamide adenine dinucleotide-glycohydrolase and ADP-ribosyl cyclase activities in these blood vessels. Both enzymes appear to be associated with the membrane fraction, and therefore might be attributed to CD38. These data demonstrate a previously uncharacterized localization of CD38 in perivascular autonomic nerve terminals. Therefore, the β-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2006.01.043</identifier><identifier>PMID: 16580146</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>ADP-ribosyl Cyclase 1 - metabolism ; Animals ; artery ; Biological and medical sciences ; Blood Vessels - cytology ; Blood Vessels - metabolism ; Blotting, Western - methods ; Chromatography, High Pressure Liquid - methods ; Dogs ; Female ; Fundamental and applied biological sciences. Psychology ; Ganglia, Sympathetic - cytology ; Guanine Nucleotides - metabolism ; Immunohistochemistry - methods ; Male ; NAD - analogs & derivatives ; NAD - metabolism ; nerve terminals ; Nerve Tissue Proteins - metabolism ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Presynaptic Terminals - metabolism ; Subcellular Fractions - metabolism ; sympathetic ; Tyrosine 3-Monooxygenase - metabolism ; vascular neuromuscular junction ; vein ; Vertebrates: nervous system and sense organs ; β-NAD</subject><ispartof>Neuroscience, 2006, Vol.139 (4), p.1467-1477</ispartof><rights>2006 IBRO</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-1ccf4c0861a7c00268a9e7220f0d984b8df1062a2eb0a8c36a4e641fd363cecb3</citedby><cites>FETCH-LOGICAL-c439t-1ccf4c0861a7c00268a9e7220f0d984b8df1062a2eb0a8c36a4e641fd363cecb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2006.01.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17772159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16580146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smyth, L.M.</creatorcontrib><creatorcontrib>Breen, L.T.</creatorcontrib><creatorcontrib>Yamboliev, I.A.</creatorcontrib><creatorcontrib>Mutafova-Yambolieva, V.N.</creatorcontrib><title>Novel localization of CD38 in perivascular sympathetic nerve terminals</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Using high performance liquid chromatography fraction analysis we have recently established that numerous smooth muscle preparations, including the canine mesenteric artery and vein, release β-nicotinamide adenine dinucleotide upon short-pulse electrical field stimulation in tetrodotoxin- and ω-conotoxin GVIA-sensitive manners [
Smyth LM, Bobalova J, Mendoza MG, Lew C, Mutafova-Yambolieva VN (2004) Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem 279:48893–48903.]. The β-nicotinamide adenine dinucleotide metabolites ADP-ribose and cyclic ADP-ribose are also present in the tissue superfusates. CD38 is a multifunctional enzyme involved in the degradation of β-nicotinamide adenine dinucleotide to ADP-ribose and cyclic ADP-ribose. Western immunoblot analysis revealed that CD38 is expressed in both artery and vein. Confocal laser scanning microscopy established colocalization of CD38 with tyrosine hydroxylase, synaptotagmin and synaptic vesicle protein in both blood vessels. High performance liquid chromatography with fluorescence detection demonstrated that whole tissue segments metabolize 1,
N
6-etheno-nicotinamide adenine dinucleotide to 1,
N
6-etheno-ADP-ribose and nicotinamide-guanine dinucleotide to cyclic GDP-ribose, suggesting the presence of both nicotinamide adenine dinucleotide-glycohydrolase and ADP-ribosyl cyclase activities in these blood vessels. Both enzymes appear to be associated with the membrane fraction, and therefore might be attributed to CD38. These data demonstrate a previously uncharacterized localization of CD38 in perivascular autonomic nerve terminals. Therefore, the β-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control.</description><subject>ADP-ribosyl Cyclase 1 - metabolism</subject><subject>Animals</subject><subject>artery</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - cytology</subject><subject>Blood Vessels - metabolism</subject><subject>Blotting, Western - methods</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dogs</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Sympathetic - cytology</subject><subject>Guanine Nucleotides - metabolism</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>NAD - analogs & derivatives</subject><subject>NAD - metabolism</subject><subject>nerve terminals</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Presynaptic Terminals - metabolism</subject><subject>Subcellular Fractions - metabolism</subject><subject>sympathetic</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>vascular neuromuscular junction</subject><subject>vein</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>β-NAD</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1r3DAQhkVJabZp_0IwgeRmZ0aSJbu3sknaQGgvyVlo5THR4o-NZC-kvz5a1pDe2rnM5Zl5Xx7GLhAKBFTX22KgOYzReRocFRxAFYAFSPGBrbDSItellCdsBQJULkvOT9nnGLeQppTiEztFVVaAUq3Y3a9xT13Wjc52_o-d_DhkY5utb0SV-SHbUfB7G93c2ZDF135np2eavMsGCnvKJgq9H2wXv7CPbVr0ddln7Onu9nH9M3_4_eN-_f0hd1LUU47OtdJBpdBqB8BVZWvSnEMLTV3JTdW0CIpbThuwlRPKSlIS20Yo4chtxBm7Ov7dhfFlpjiZ3kdHXWcHGudolK4lSIn_BFGjUqKuE_jtCLpkNAZqzS743oZXg2AOus3W_K3bHHQbQJN0p-PzJWXe9NS8ny5-E3C5AEmi7dpgB-fjO6e15lgeWtwcOUry9p6CWeIaH8hNphn9__R5A5bRpQE</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Smyth, L.M.</creator><creator>Breen, L.T.</creator><creator>Yamboliev, I.A.</creator><creator>Mutafova-Yambolieva, V.N.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Novel localization of CD38 in perivascular sympathetic nerve terminals</title><author>Smyth, L.M. ; Breen, L.T. ; Yamboliev, I.A. ; Mutafova-Yambolieva, V.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-1ccf4c0861a7c00268a9e7220f0d984b8df1062a2eb0a8c36a4e641fd363cecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ADP-ribosyl Cyclase 1 - metabolism</topic><topic>Animals</topic><topic>artery</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - cytology</topic><topic>Blood Vessels - metabolism</topic><topic>Blotting, Western - methods</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dogs</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Sympathetic - cytology</topic><topic>Guanine Nucleotides - metabolism</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>NAD - analogs & derivatives</topic><topic>NAD - metabolism</topic><topic>nerve terminals</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Presynaptic Terminals - metabolism</topic><topic>Subcellular Fractions - metabolism</topic><topic>sympathetic</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>vascular neuromuscular junction</topic><topic>vein</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>β-NAD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smyth, L.M.</creatorcontrib><creatorcontrib>Breen, L.T.</creatorcontrib><creatorcontrib>Yamboliev, I.A.</creatorcontrib><creatorcontrib>Mutafova-Yambolieva, V.N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smyth, L.M.</au><au>Breen, L.T.</au><au>Yamboliev, I.A.</au><au>Mutafova-Yambolieva, V.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel localization of CD38 in perivascular sympathetic nerve terminals</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006</date><risdate>2006</risdate><volume>139</volume><issue>4</issue><spage>1467</spage><epage>1477</epage><pages>1467-1477</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Using high performance liquid chromatography fraction analysis we have recently established that numerous smooth muscle preparations, including the canine mesenteric artery and vein, release β-nicotinamide adenine dinucleotide upon short-pulse electrical field stimulation in tetrodotoxin- and ω-conotoxin GVIA-sensitive manners [
Smyth LM, Bobalova J, Mendoza MG, Lew C, Mutafova-Yambolieva VN (2004) Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem 279:48893–48903.]. The β-nicotinamide adenine dinucleotide metabolites ADP-ribose and cyclic ADP-ribose are also present in the tissue superfusates. CD38 is a multifunctional enzyme involved in the degradation of β-nicotinamide adenine dinucleotide to ADP-ribose and cyclic ADP-ribose. Western immunoblot analysis revealed that CD38 is expressed in both artery and vein. Confocal laser scanning microscopy established colocalization of CD38 with tyrosine hydroxylase, synaptotagmin and synaptic vesicle protein in both blood vessels. High performance liquid chromatography with fluorescence detection demonstrated that whole tissue segments metabolize 1,
N
6-etheno-nicotinamide adenine dinucleotide to 1,
N
6-etheno-ADP-ribose and nicotinamide-guanine dinucleotide to cyclic GDP-ribose, suggesting the presence of both nicotinamide adenine dinucleotide-glycohydrolase and ADP-ribosyl cyclase activities in these blood vessels. Both enzymes appear to be associated with the membrane fraction, and therefore might be attributed to CD38. These data demonstrate a previously uncharacterized localization of CD38 in perivascular autonomic nerve terminals. Therefore, the β-nicotinamide adenine dinucleotide/CD38 system may provide new mechanisms in autonomic neurovascular control.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16580146</pmid><doi>10.1016/j.neuroscience.2006.01.043</doi><tpages>11</tpages></addata></record> |
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| subjects | ADP-ribosyl Cyclase 1 - metabolism Animals artery Biological and medical sciences Blood Vessels - cytology Blood Vessels - metabolism Blotting, Western - methods Chromatography, High Pressure Liquid - methods Dogs Female Fundamental and applied biological sciences. Psychology Ganglia, Sympathetic - cytology Guanine Nucleotides - metabolism Immunohistochemistry - methods Male NAD - analogs & derivatives NAD - metabolism nerve terminals Nerve Tissue Proteins - metabolism Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Presynaptic Terminals - metabolism Subcellular Fractions - metabolism sympathetic Tyrosine 3-Monooxygenase - metabolism vascular neuromuscular junction vein Vertebrates: nervous system and sense organs β-NAD |
| title | Novel localization of CD38 in perivascular sympathetic nerve terminals |
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