Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

Histone methylation regulates chromatin structure, transcription, and epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases such as LSD1 and JHDM1, which mediate demethylation of di- and monomethylated histones. It has been unclear whether...

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Veröffentlicht in:	Cell 2006-05, Vol.125 (3), p.467-481
Hauptverfasser:	Whetstine, Johnathan R., Nottke, Amanda, Lan, Fei, Huarte, Maite, Smolikov, Sarit, Chen, Zhongzhou, Spooner, Eric, Li, En, Zhang, Gongyi, Colaiacovo, Monica, Shi, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Catalytic Domain Cell Differentiation - physiology Chromosomes - genetics Chromosomes - metabolism DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation - physiology Germ Cells - cytology Germ Cells - metabolism HeLa Cells Histones - chemistry Histones - metabolism Humans Jumonji Domain-Containing Histone Demethylases Lysine - metabolism Meiosis - physiology Mutation Oxidoreductases, N-Demethylating Rad51 Recombinase - genetics Rad51 Recombinase - metabolism RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Protein p53 - metabolism
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