Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

Objective Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs. However, the impact of OATP1B1*1b alleles, the frequency of which is high in all ethnicities, on the pharmacokinetics of substrate drug...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2006-05, Vol.79 (5), p.427-439
Hauptverfasser:	Maeda, Kazuya, Ieiri, Ichiro, Yasuda, Kuninobu, Fujino, Akiharu, Fujiwara, Hiroaki, Otsubo, Kenji, Hirano, Masaru, Watanabe, Takao, Kitamura, Yoshiaki, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antihypertensive Agents - blood Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - urine Area Under Curve Biological and medical sciences Cells, Cultured Cross-Over Studies Dogs Haplotypes Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Hydroxymethylglutaryl-CoA Reductase Inhibitors - urine Male Medical sciences Metabolic Clearance Rate Organic Anion Transporters - genetics Pharmacology. Drug treatments Polymorphism, Genetic Pravastatin - blood Pravastatin - pharmacokinetics Pravastatin - urine Solute Carrier Organic Anion Transporter Family Member 1b1 Tetrazoles - blood Tetrazoles - pharmacokinetics Tetrazoles - urine Thiazepines - blood Thiazepines - pharmacokinetics Thiazepines - urine Valine - analogs & derivatives Valine - blood Valine - pharmacokinetics Valine - urine Valsartan
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