Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein

Wnt signaling pathways are important for multiple biological processes during development and disease. Wnt proteins are secreted factors that activate target-gene expression in both a short- and long-range manner. Currently, little is known about how Wnts are released from cells and which factors fa...

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Veröffentlicht in:	Cell 2006-05, Vol.125 (3), p.523-533
Hauptverfasser:	Bartscherer, Kerstin, Pelte, Nadège, Ingelfinger, Dierk, Boutros, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning - genetics Cell Line Cell Lineage - genetics Cells, Cultured Clone Cells - metabolism Conserved Sequence - genetics Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - isolation & purification Drosophila Proteins - metabolism Evolution, Molecular Gene Expression Regulation, Developmental - physiology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - isolation & purification Intracellular Signaling Peptides and Proteins - metabolism Membrane Proteins - genetics Membrane Proteins - isolation & purification Membrane Proteins - metabolism Mutation - genetics Phenotype RNA Interference Signal Transduction - physiology Wnt Proteins - metabolism
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