Fmoc solid-phase synthesis of peptide thioesters using an intramolecularn,S-acyl shift

[reaction: see text] We describe the Fmoc solid-phase synthesis of peptide thioesters based on the alkylation of the safety-catch sulfonamide linker with a protected 2-mercaptoethanol derivative. The thioester is generated on the solid phase after the peptide chain assembly as a consequence of an in...

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Veröffentlicht in:	Organic letters 2005-06, Vol.7 (13), p.2647-2650
Hauptverfasser:	Ollivier, Nathalie, Behr, Jean-Bernard, El-Mahdi, Ouafâa, Blanpain, Annick, Melnyk, Oleg
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemistry Combinatorial Chemistry Techniques Esters Molecular Sequence Data Peptides - chemical synthesis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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