Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice

Ghrelin and leptin are suggested to regulate energy homeostasis as mutual antagonists on hypothalamic neurons that regulate feeding behavior. We employed reverse genetics to investigate the interplay between ghrelin and leptin. Leptin-deficient mice ( ob/ob) are hyperphagic, obese, and hyperglycemic...

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Veröffentlicht in:	Cell metabolism 2006-05, Vol.3 (5), p.379-386
Hauptverfasser:	Sun, Yuxiang, Asnicar, Mark, Saha, Pradip K., Chan, Lawrence, Smith, Roy G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Body Temperature Regulation Body Weight Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Down-Regulation Ghrelin Insulin - blood Ion Channels - genetics Ion Channels - metabolism Leptin - genetics Leptin - metabolism Leptin - physiology Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Obesity - blood Obesity - metabolism Obesity - physiopathology Pancreas - metabolism Peptide Hormones - genetics Peptide Hormones - metabolism Peptide Hormones - physiology Phenotype RNA, Messenger - metabolism Uncoupling Protein 2
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