Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats
Diuretic and uricosuric properties have traditionally been attributed to corn silk, stigma/style of Zea mays L. Although the diuretic effect was confirmed, studies of the plant's effects on renal function or solute excretion were lacking. Thus, we studied the effects of corn silk aqueous extrac...
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| creator | Velazquez, D.V.O. Xavier, H.S. Batista, J.E.M. de Castro-Chaves, C. |
| description | Diuretic and uricosuric properties have traditionally been attributed to corn silk, stigma/style of
Zea mays L. Although the diuretic effect was confirmed, studies of the plant's effects on renal function or solute excretion were lacking. Thus, we studied the effects of corn silk aqueous extract on the urinary excretion of water, Na
+, K
+, and uric acid. Glomerular and proximal tubular function and Na
+ tubular handling were also studied. Conscious, unrestrained adult male rats were housed in individual metabolic cages (IMC) with continuous urine collection for 5 and 3
h, following two protocols. The effects of 25, 50, 200, 350, and 500
mg/kg body wt. corn silk extract on urine volume plus Na
+ and K
+ excretions were studied in water-loaded conscious rats (2.5
ml/100
g body wt.) in the IMC for 5
h (Protocol 1). Kaliuresis was observed with doses of 350 (100.42±22.32–120.28±19.70
μEq/5
h/100
g body wt.;
n
=
13
) and 500
mg/kg body wt. (94.97±29.30–134.32±39.98
μEq/5
h/100
g body wt.;
n
=
12
;
p
<
0.01
), and the latter dose resulted in diuresis as well (1.98±0.44–2.41±0.41
ml/5
h/100
g body wt.;
n
=
12
;
p
<
0.05
). The effects of a 500
mg/kg body wt. dose of corn silk extract on urine volume, Na
+, K
+ and uric acid excretions, and glomerular and proximal tubular function, were measured respectively by creatinine (Cl
cr) and Li
+ (Cl
Li) clearances and Na
+ tubular handling, in water-loaded rats (5
ml/100
g body wt.) in the IMC for 3
h (Protocol 2). Cl
cr (294.6±73.2,
n
=
12
, to 241.7±48.0
μl/min/100
g body wt.;
n
=
13
;
p
<
0.05
) and the Na
+ filtered load (41.9±10.3,
n
=
12
, to 34.3±.8,
n
=
13
,
p
<
0.05
) decreased and Cl
Li and Na
+ excretion were unchanged, while K
+ excretion (0.1044±0.0458,
n
=
12
, to 0.2289±0.0583
μEq/min/100
body wt.;
n
=
13
;
p
<
0.001
) increased. For Na
+ tubular handling, the fractional proximal tubular reabsorption (91.5±3.5,
n
=
12
, to 87.5±3.4%;
n
=
13
;
p
<
0.01
) decreased, and both fractional distal reabsorptions — I and II — increased (96.5±1.5,
n
=
12
, to 97.8±0.9%;
n
=
13
;
p
<
0.01
; and 8.2±3.5,
n
=
12
, to 12.2±3.4%,
n
=
13
,
p
<
0.01
, respectively). To summarize, in water-loaded conscious rats (2.5
ml/100 body wt.), corn silk aqueous extract is diuretic at a dose of 500
mg/kg body wt. and kaliuretic at doses of 350 and 500
mg/kg body wt. In water-loaded conscious rats (5.0
ml/100
g body wt.), corn silk aqueous extract is kaliuretic at a dose of 500
mg/kg body wt., but glomerular filtration and filtered lo |
| doi_str_mv | 10.1016/j.phymed.2003.12.010 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67937046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A134958039</galeid><els_id>S0944711305000218</els_id><sourcerecordid>A134958039</sourcerecordid><originalsourceid>FETCH-LOGICAL-c582t-2c5295b39b8f8ca278826a78b81941348c69b2877004cc4c3e6937403c8b4a963</originalsourceid><addsrcrecordid>eNp9kl-L1DAUxYso7uzqNxANCr615l-b5GVhWVwVBnzQBfElpOntmKFNxqQV59ub2kFQBslDIPd3Lif3nqJ4RnBFMGne7KvDt-MIXUUxZhWhFSb4QbEhDZElVvWXh8UGK85LQQi7KC5T2mNMuBL4cXFBalULJsimMF_BoNEcE9pWCH5O0dgpoTF0rj-i3RBGiPNgIupnbycXPDK-Q4cwmZTcPKI5Om_iMStthN9155ENPlkX5oSimdKT4lFvhgRPT_dVcX_39vPt-3L78d2H25ttaWtJp5Lamqq6ZaqVvbSGCilpY4RsJVGcMC5to1oqhcCYW8stg0YxwTGzsuVGNeyqeL32PcTwfYY06dElC8NgPGQvuhGZx3wBX_4D7sMcffamKa5rRlVDMvRqhXZmAO18H5bRLB31TXajaomZylR5htqBh2iG4KF3-fkvvjrD59PB6OxZAV8FNoaUIvT6EN2YJ64J1ksM9F6vMdBLDDShOscgy56fvji3S-2P6LT3DLxYgd4EbXbRJX3_iWLCspoyIWkmrlcC8s5-OIg67xS8hc5FsJPugvu_h1-mGMwH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205532961</pqid></control><display><type>article</type><title>Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Velazquez, D.V.O. ; Xavier, H.S. ; Batista, J.E.M. ; de Castro-Chaves, C.</creator><creatorcontrib>Velazquez, D.V.O. ; Xavier, H.S. ; Batista, J.E.M. ; de Castro-Chaves, C.</creatorcontrib><description><![CDATA[Diuretic and uricosuric properties have traditionally been attributed to corn silk, stigma/style of
Zea mays L. Although the diuretic effect was confirmed, studies of the plant's effects on renal function or solute excretion were lacking. Thus, we studied the effects of corn silk aqueous extract on the urinary excretion of water, Na
+, K
+, and uric acid. Glomerular and proximal tubular function and Na
+ tubular handling were also studied. Conscious, unrestrained adult male rats were housed in individual metabolic cages (IMC) with continuous urine collection for 5 and 3
h, following two protocols. The effects of 25, 50, 200, 350, and 500
mg/kg body wt. corn silk extract on urine volume plus Na
+ and K
+ excretions were studied in water-loaded conscious rats (2.5
ml/100
g body wt.) in the IMC for 5
h (Protocol 1). Kaliuresis was observed with doses of 350 (100.42±22.32–120.28±19.70
μEq/5
h/100
g body wt.;
n
=
13
) and 500
mg/kg body wt. (94.97±29.30–134.32±39.98
μEq/5
h/100
g body wt.;
n
=
12
;
p
<
0.01
), and the latter dose resulted in diuresis as well (1.98±0.44–2.41±0.41
ml/5
h/100
g body wt.;
n
=
12
;
p
<
0.05
). The effects of a 500
mg/kg body wt. dose of corn silk extract on urine volume, Na
+, K
+ and uric acid excretions, and glomerular and proximal tubular function, were measured respectively by creatinine (Cl
cr) and Li
+ (Cl
Li) clearances and Na
+ tubular handling, in water-loaded rats (5
ml/100
g body wt.) in the IMC for 3
h (Protocol 2). Cl
cr (294.6±73.2,
n
=
12
, to 241.7±48.0
μl/min/100
g body wt.;
n
=
13
;
p
<
0.05
) and the Na
+ filtered load (41.9±10.3,
n
=
12
, to 34.3±.8,
n
=
13
,
p
<
0.05
) decreased and Cl
Li and Na
+ excretion were unchanged, while K
+ excretion (0.1044±0.0458,
n
=
12
, to 0.2289±0.0583
μEq/min/100
body wt.;
n
=
13
;
p
<
0.001
) increased. For Na
+ tubular handling, the fractional proximal tubular reabsorption (91.5±3.5,
n
=
12
, to 87.5±3.4%;
n
=
13
;
p
<
0.01
) decreased, and both fractional distal reabsorptions — I and II — increased (96.5±1.5,
n
=
12
, to 97.8±0.9%;
n
=
13
;
p
<
0.01
; and 8.2±3.5,
n
=
12
, to 12.2±3.4%,
n
=
13
,
p
<
0.01
, respectively). To summarize, in water-loaded conscious rats (2.5
ml/100 body wt.), corn silk aqueous extract is diuretic at a dose of 500
mg/kg body wt. and kaliuretic at doses of 350 and 500
mg/kg body wt. In water-loaded conscious rats (5.0
ml/100
g body wt.), corn silk aqueous extract is kaliuretic at a dose of 500
mg/kg body wt., but glomerular filtration and filtered load decrease without affecting proximal tubular function, Na
+, or uric acid excretion.]]></description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2003.12.010</identifier><identifier>PMID: 15957371</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Analysis ; Animals ; Conscious rats ; Corn ; Corn silk aqueous extract ; Diuresis ; diuretics ; Diuretics - administration & dosage ; Diuretics - pharmacology ; Diuretics - therapeutic use ; Dose-Response Relationship, Drug ; excretion ; Female ; glomerular filtration rate ; Glomerular Filtration Rate - drug effects ; Glomerular function ; Homeopathy ; Kaliuresis ; Kidney - drug effects ; Kidney - physiology ; Male ; Materia medica and therapeutics ; medicinal properties ; Mice ; Na + tubular handling ; Natriuresis ; Phytotherapy ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plants ; potassium ; Potassium - urine ; Potassium compounds ; Proximal tubule function ; Rats ; Rats, Wistar ; renal function ; sodium ; styles ; Testing ; Therapeutics ; uric acid ; urine ; Zea mays ; Zea mays Linne</subject><ispartof>Phytomedicine (Stuttgart), 2005-05, Vol.12 (5), p.363-369</ispartof><rights>2005 Elsevier GmbH</rights><rights>COPYRIGHT 2005 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-2c5295b39b8f8ca278826a78b81941348c69b2877004cc4c3e6937403c8b4a963</citedby><cites>FETCH-LOGICAL-c582t-2c5295b39b8f8ca278826a78b81941348c69b2877004cc4c3e6937403c8b4a963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711305000218$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15957371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velazquez, D.V.O.</creatorcontrib><creatorcontrib>Xavier, H.S.</creatorcontrib><creatorcontrib>Batista, J.E.M.</creatorcontrib><creatorcontrib>de Castro-Chaves, C.</creatorcontrib><title>Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description><![CDATA[Diuretic and uricosuric properties have traditionally been attributed to corn silk, stigma/style of
Zea mays L. Although the diuretic effect was confirmed, studies of the plant's effects on renal function or solute excretion were lacking. Thus, we studied the effects of corn silk aqueous extract on the urinary excretion of water, Na
+, K
+, and uric acid. Glomerular and proximal tubular function and Na
+ tubular handling were also studied. Conscious, unrestrained adult male rats were housed in individual metabolic cages (IMC) with continuous urine collection for 5 and 3
h, following two protocols. The effects of 25, 50, 200, 350, and 500
mg/kg body wt. corn silk extract on urine volume plus Na
+ and K
+ excretions were studied in water-loaded conscious rats (2.5
ml/100
g body wt.) in the IMC for 5
h (Protocol 1). Kaliuresis was observed with doses of 350 (100.42±22.32–120.28±19.70
μEq/5
h/100
g body wt.;
n
=
13
) and 500
mg/kg body wt. (94.97±29.30–134.32±39.98
μEq/5
h/100
g body wt.;
n
=
12
;
p
<
0.01
), and the latter dose resulted in diuresis as well (1.98±0.44–2.41±0.41
ml/5
h/100
g body wt.;
n
=
12
;
p
<
0.05
). The effects of a 500
mg/kg body wt. dose of corn silk extract on urine volume, Na
+, K
+ and uric acid excretions, and glomerular and proximal tubular function, were measured respectively by creatinine (Cl
cr) and Li
+ (Cl
Li) clearances and Na
+ tubular handling, in water-loaded rats (5
ml/100
g body wt.) in the IMC for 3
h (Protocol 2). Cl
cr (294.6±73.2,
n
=
12
, to 241.7±48.0
μl/min/100
g body wt.;
n
=
13
;
p
<
0.05
) and the Na
+ filtered load (41.9±10.3,
n
=
12
, to 34.3±.8,
n
=
13
,
p
<
0.05
) decreased and Cl
Li and Na
+ excretion were unchanged, while K
+ excretion (0.1044±0.0458,
n
=
12
, to 0.2289±0.0583
μEq/min/100
body wt.;
n
=
13
;
p
<
0.001
) increased. For Na
+ tubular handling, the fractional proximal tubular reabsorption (91.5±3.5,
n
=
12
, to 87.5±3.4%;
n
=
13
;
p
<
0.01
) decreased, and both fractional distal reabsorptions — I and II — increased (96.5±1.5,
n
=
12
, to 97.8±0.9%;
n
=
13
;
p
<
0.01
; and 8.2±3.5,
n
=
12
, to 12.2±3.4%,
n
=
13
,
p
<
0.01
, respectively). To summarize, in water-loaded conscious rats (2.5
ml/100 body wt.), corn silk aqueous extract is diuretic at a dose of 500
mg/kg body wt. and kaliuretic at doses of 350 and 500
mg/kg body wt. In water-loaded conscious rats (5.0
ml/100
g body wt.), corn silk aqueous extract is kaliuretic at a dose of 500
mg/kg body wt., but glomerular filtration and filtered load decrease without affecting proximal tubular function, Na
+, or uric acid excretion.]]></description><subject>Analysis</subject><subject>Animals</subject><subject>Conscious rats</subject><subject>Corn</subject><subject>Corn silk aqueous extract</subject><subject>Diuresis</subject><subject>diuretics</subject><subject>Diuretics - administration & dosage</subject><subject>Diuretics - pharmacology</subject><subject>Diuretics - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>excretion</subject><subject>Female</subject><subject>glomerular filtration rate</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Glomerular function</subject><subject>Homeopathy</subject><subject>Kaliuresis</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>Materia medica and therapeutics</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Na + tubular handling</subject><subject>Natriuresis</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plants</subject><subject>potassium</subject><subject>Potassium - urine</subject><subject>Potassium compounds</subject><subject>Proximal tubule function</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>renal function</subject><subject>sodium</subject><subject>styles</subject><subject>Testing</subject><subject>Therapeutics</subject><subject>uric acid</subject><subject>urine</subject><subject>Zea mays</subject><subject>Zea mays Linne</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl-L1DAUxYso7uzqNxANCr615l-b5GVhWVwVBnzQBfElpOntmKFNxqQV59ub2kFQBslDIPd3Lif3nqJ4RnBFMGne7KvDt-MIXUUxZhWhFSb4QbEhDZElVvWXh8UGK85LQQi7KC5T2mNMuBL4cXFBalULJsimMF_BoNEcE9pWCH5O0dgpoTF0rj-i3RBGiPNgIupnbycXPDK-Q4cwmZTcPKI5Om_iMStthN9155ENPlkX5oSimdKT4lFvhgRPT_dVcX_39vPt-3L78d2H25ttaWtJp5Lamqq6ZaqVvbSGCilpY4RsJVGcMC5to1oqhcCYW8stg0YxwTGzsuVGNeyqeL32PcTwfYY06dElC8NgPGQvuhGZx3wBX_4D7sMcffamKa5rRlVDMvRqhXZmAO18H5bRLB31TXajaomZylR5htqBh2iG4KF3-fkvvjrD59PB6OxZAV8FNoaUIvT6EN2YJ64J1ksM9F6vMdBLDDShOscgy56fvji3S-2P6LT3DLxYgd4EbXbRJX3_iWLCspoyIWkmrlcC8s5-OIg67xS8hc5FsJPugvu_h1-mGMwH</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Velazquez, D.V.O.</creator><creator>Xavier, H.S.</creator><creator>Batista, J.E.M.</creator><creator>de Castro-Chaves, C.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats</title><author>Velazquez, D.V.O. ; Xavier, H.S. ; Batista, J.E.M. ; de Castro-Chaves, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-2c5295b39b8f8ca278826a78b81941348c69b2877004cc4c3e6937403c8b4a963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Conscious rats</topic><topic>Corn</topic><topic>Corn silk aqueous extract</topic><topic>Diuresis</topic><topic>diuretics</topic><topic>Diuretics - administration & dosage</topic><topic>Diuretics - pharmacology</topic><topic>Diuretics - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>excretion</topic><topic>Female</topic><topic>glomerular filtration rate</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Glomerular function</topic><topic>Homeopathy</topic><topic>Kaliuresis</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiology</topic><topic>Male</topic><topic>Materia medica and therapeutics</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Na + tubular handling</topic><topic>Natriuresis</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plants</topic><topic>potassium</topic><topic>Potassium - urine</topic><topic>Potassium compounds</topic><topic>Proximal tubule function</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>renal function</topic><topic>sodium</topic><topic>styles</topic><topic>Testing</topic><topic>Therapeutics</topic><topic>uric acid</topic><topic>urine</topic><topic>Zea mays</topic><topic>Zea mays Linne</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velazquez, D.V.O.</creatorcontrib><creatorcontrib>Xavier, H.S.</creatorcontrib><creatorcontrib>Batista, J.E.M.</creatorcontrib><creatorcontrib>de Castro-Chaves, C.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velazquez, D.V.O.</au><au>Xavier, H.S.</au><au>Batista, J.E.M.</au><au>de Castro-Chaves, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>12</volume><issue>5</issue><spage>363</spage><epage>369</epage><pages>363-369</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract><![CDATA[Diuretic and uricosuric properties have traditionally been attributed to corn silk, stigma/style of
Zea mays L. Although the diuretic effect was confirmed, studies of the plant's effects on renal function or solute excretion were lacking. Thus, we studied the effects of corn silk aqueous extract on the urinary excretion of water, Na
+, K
+, and uric acid. Glomerular and proximal tubular function and Na
+ tubular handling were also studied. Conscious, unrestrained adult male rats were housed in individual metabolic cages (IMC) with continuous urine collection for 5 and 3
h, following two protocols. The effects of 25, 50, 200, 350, and 500
mg/kg body wt. corn silk extract on urine volume plus Na
+ and K
+ excretions were studied in water-loaded conscious rats (2.5
ml/100
g body wt.) in the IMC for 5
h (Protocol 1). Kaliuresis was observed with doses of 350 (100.42±22.32–120.28±19.70
μEq/5
h/100
g body wt.;
n
=
13
) and 500
mg/kg body wt. (94.97±29.30–134.32±39.98
μEq/5
h/100
g body wt.;
n
=
12
;
p
<
0.01
), and the latter dose resulted in diuresis as well (1.98±0.44–2.41±0.41
ml/5
h/100
g body wt.;
n
=
12
;
p
<
0.05
). The effects of a 500
mg/kg body wt. dose of corn silk extract on urine volume, Na
+, K
+ and uric acid excretions, and glomerular and proximal tubular function, were measured respectively by creatinine (Cl
cr) and Li
+ (Cl
Li) clearances and Na
+ tubular handling, in water-loaded rats (5
ml/100
g body wt.) in the IMC for 3
h (Protocol 2). Cl
cr (294.6±73.2,
n
=
12
, to 241.7±48.0
μl/min/100
g body wt.;
n
=
13
;
p
<
0.05
) and the Na
+ filtered load (41.9±10.3,
n
=
12
, to 34.3±.8,
n
=
13
,
p
<
0.05
) decreased and Cl
Li and Na
+ excretion were unchanged, while K
+ excretion (0.1044±0.0458,
n
=
12
, to 0.2289±0.0583
μEq/min/100
body wt.;
n
=
13
;
p
<
0.001
) increased. For Na
+ tubular handling, the fractional proximal tubular reabsorption (91.5±3.5,
n
=
12
, to 87.5±3.4%;
n
=
13
;
p
<
0.01
) decreased, and both fractional distal reabsorptions — I and II — increased (96.5±1.5,
n
=
12
, to 97.8±0.9%;
n
=
13
;
p
<
0.01
; and 8.2±3.5,
n
=
12
, to 12.2±3.4%,
n
=
13
,
p
<
0.01
, respectively). To summarize, in water-loaded conscious rats (2.5
ml/100 body wt.), corn silk aqueous extract is diuretic at a dose of 500
mg/kg body wt. and kaliuretic at doses of 350 and 500
mg/kg body wt. In water-loaded conscious rats (5.0
ml/100
g body wt.), corn silk aqueous extract is kaliuretic at a dose of 500
mg/kg body wt., but glomerular filtration and filtered load decrease without affecting proximal tubular function, Na
+, or uric acid excretion.]]></abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>15957371</pmid><doi>10.1016/j.phymed.2003.12.010</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2005-05, Vol.12 (5), p.363-369 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67937046 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Animals Conscious rats Corn Corn silk aqueous extract Diuresis diuretics Diuretics - administration & dosage Diuretics - pharmacology Diuretics - therapeutic use Dose-Response Relationship, Drug excretion Female glomerular filtration rate Glomerular Filtration Rate - drug effects Glomerular function Homeopathy Kaliuresis Kidney - drug effects Kidney - physiology Male Materia medica and therapeutics medicinal properties Mice Na + tubular handling Natriuresis Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants potassium Potassium - urine Potassium compounds Proximal tubule function Rats Rats, Wistar renal function sodium styles Testing Therapeutics uric acid urine Zea mays Zea mays Linne |
| title | Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A56%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zea%20mays%20L.%20extracts%20modify%20glomerular%20function%20and%20potassium%20urinary%20excretion%20in%20conscious%20rats&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Velazquez,%20D.V.O.&rft.date=2005-05-01&rft.volume=12&rft.issue=5&rft.spage=363&rft.epage=369&rft.pages=363-369&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1016/j.phymed.2003.12.010&rft_dat=%3Cgale_proqu%3EA134958039%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205532961&rft_id=info:pmid/15957371&rft_galeid=A134958039&rft_els_id=S0944711305000218&rfr_iscdi=true |