Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects
Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known. C-reactive protein (CRP), serum amyloid A (SAA), and lipoprotein levels were comp...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2005-06, Vol.111 (23), p.3058-3062 |
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| creator | TANNOCK, Lisa R O'BRIEN, Kevin D KNOPP, Robert H RETZLAFF, Barbara FISH, Brian WENER, Mark H KAHN, Steven E CHAIT, Alan |
| description | Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known.
C-reactive protein (CRP), serum amyloid A (SAA), and lipoprotein levels were compared in 201 healthy subjects on an American Heart Association-National Cholesterol Education Program step 1 diet at baseline and after addition of 4 eggs per day for 4 weeks. Subjects were classified a priori into 3 groups based on their body mass index (BMI) and insulin sensitivity index (SI): lean insulin sensitive (LIS), mean+/-SEM BMI, 23.2+/-0.3 kg/m2, and SI, 6.7+/-0.3x10(-4)min(-1)/(microU/mL), n=66; lean insulin resistant (LIR), BMI, 24.5+/-0.2 kg/m2 and SI, 2.9+/-0.1x10(-4)min(-1)/(microU/mL), n=76; or obese insulin resistant (OIR), BMI, 31.4+/-0.5 kg/m2 and SI, 2.1+/-0.1x10(-4)min(-1)/(microU/mL), n=59. Insulin resistance and obesity each were associated with increased baseline levels of both CRP (P for trend, |
| doi_str_mv | 10.1161/CIRCULATIONAHA.104.506188 |
| format | Article |
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C-reactive protein (CRP), serum amyloid A (SAA), and lipoprotein levels were compared in 201 healthy subjects on an American Heart Association-National Cholesterol Education Program step 1 diet at baseline and after addition of 4 eggs per day for 4 weeks. Subjects were classified a priori into 3 groups based on their body mass index (BMI) and insulin sensitivity index (SI): lean insulin sensitive (LIS), mean+/-SEM BMI, 23.2+/-0.3 kg/m2, and SI, 6.7+/-0.3x10(-4)min(-1)/(microU/mL), n=66; lean insulin resistant (LIR), BMI, 24.5+/-0.2 kg/m2 and SI, 2.9+/-0.1x10(-4)min(-1)/(microU/mL), n=76; or obese insulin resistant (OIR), BMI, 31.4+/-0.5 kg/m2 and SI, 2.1+/-0.1x10(-4)min(-1)/(microU/mL), n=59. Insulin resistance and obesity each were associated with increased baseline levels of both CRP (P for trend, <0.001) and SAA (P for trend=0.015). Egg feeding was associated with significant increases in both CRP and SAA in the LIS group (both P<0.01) but not in the LIR or OIR groups. Egg feeding also was associated with a significant increase in non-HDL cholesterol (P<0.001) in LIS subjects; however, there was no correlation between the change in non-HDL cholesterol or changes in either CRP or SAA in this group.
A high-cholesterol diet leads to significant increases in both inflammatory markers and non-HDL cholesterol levels in insulin-sensitive individuals but not in lean or obese insulin-resistant subjects.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.104.506188</identifier><identifier>PMID: 15939816</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acute-Phase Proteins - analysis ; Associated diseases and complications ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Body Weight ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cholesterol, Dietary - administration & dosage ; Cholesterol, Dietary - pharmacology ; Diabetes. Impaired glucose tolerance ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Humans ; Inflammation ; Insulin Resistance ; Male ; Medical sciences ; Middle Aged ; Obesity ; Serum Amyloid A Protein - analysis ; Thinness ; Up-Regulation - drug effects</subject><ispartof>Circulation (New York, N.Y.), 2005-06, Vol.111 (23), p.3058-3062</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-9233fd4b7b337b61203147e3b4767257b19f4c23fdd5dfc12d368b811fdeee203</citedby><cites>FETCH-LOGICAL-c505t-9233fd4b7b337b61203147e3b4767257b19f4c23fdd5dfc12d368b811fdeee203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3685,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16903183$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15939816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANNOCK, Lisa R</creatorcontrib><creatorcontrib>O'BRIEN, Kevin D</creatorcontrib><creatorcontrib>KNOPP, Robert H</creatorcontrib><creatorcontrib>RETZLAFF, Barbara</creatorcontrib><creatorcontrib>FISH, Brian</creatorcontrib><creatorcontrib>WENER, Mark H</creatorcontrib><creatorcontrib>KAHN, Steven E</creatorcontrib><creatorcontrib>CHAIT, Alan</creatorcontrib><title>Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known.
C-reactive protein (CRP), serum amyloid A (SAA), and lipoprotein levels were compared in 201 healthy subjects on an American Heart Association-National Cholesterol Education Program step 1 diet at baseline and after addition of 4 eggs per day for 4 weeks. Subjects were classified a priori into 3 groups based on their body mass index (BMI) and insulin sensitivity index (SI): lean insulin sensitive (LIS), mean+/-SEM BMI, 23.2+/-0.3 kg/m2, and SI, 6.7+/-0.3x10(-4)min(-1)/(microU/mL), n=66; lean insulin resistant (LIR), BMI, 24.5+/-0.2 kg/m2 and SI, 2.9+/-0.1x10(-4)min(-1)/(microU/mL), n=76; or obese insulin resistant (OIR), BMI, 31.4+/-0.5 kg/m2 and SI, 2.1+/-0.1x10(-4)min(-1)/(microU/mL), n=59. Insulin resistance and obesity each were associated with increased baseline levels of both CRP (P for trend, <0.001) and SAA (P for trend=0.015). Egg feeding was associated with significant increases in both CRP and SAA in the LIS group (both P<0.01) but not in the LIR or OIR groups. Egg feeding also was associated with a significant increase in non-HDL cholesterol (P<0.001) in LIS subjects; however, there was no correlation between the change in non-HDL cholesterol or changes in either CRP or SAA in this group.
A high-cholesterol diet leads to significant increases in both inflammatory markers and non-HDL cholesterol levels in insulin-sensitive individuals but not in lean or obese insulin-resistant subjects.</description><subject>Acute-Phase Proteins - analysis</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body Weight</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Cholesterol, Dietary - pharmacology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Serum Amyloid A Protein - analysis</subject><subject>Thinness</subject><subject>Up-Regulation - drug effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtu1DAUhi0EotPCK6CwgF0GO77FyyiCdqQRlVC7jhz7BFw5TvFJKvXtMcxIFatz0fefy0_IR0b3jCn2pT_86O-P3d3h9nt30-0ZFXtJFWvbV2THZCNqIbl5TXaUUlNr3jQX5BLxoZSKa_mWXDBpuGmZ2pHU_1oi4Ap5idUE4EP6WYXkMlgErPq6JG4NT1A95mWFkCqbfIWQt7my83Ncgq-6KsITRCy6ktlUIm4xpBohYfgnxm18ALfiO_JmshHh_TlekftvX-_6m_p4e33ou2PtJJVrbRrOJy9GPXKuR8UaypnQwEehlW6kHpmZhGsK46WfHGs8V-3YMjZ5ACj0Ffl8mluu_r2V_4Y5oIMYbYJlw0Fpw5WguoDmBLq8IGaYhsccZpufB0aHv2YP_5td2mI4mV20H85LtnEG_6I8u1uAT2fAorNxyja5gC-cMuWvlvM_goCLCQ</recordid><startdate>20050614</startdate><enddate>20050614</enddate><creator>TANNOCK, Lisa R</creator><creator>O'BRIEN, Kevin D</creator><creator>KNOPP, Robert H</creator><creator>RETZLAFF, Barbara</creator><creator>FISH, Brian</creator><creator>WENER, Mark H</creator><creator>KAHN, Steven E</creator><creator>CHAIT, Alan</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050614</creationdate><title>Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects</title><author>TANNOCK, Lisa R ; O'BRIEN, Kevin D ; KNOPP, Robert H ; RETZLAFF, Barbara ; FISH, Brian ; WENER, Mark H ; KAHN, Steven E ; CHAIT, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-9233fd4b7b337b61203147e3b4767257b19f4c23fdd5dfc12d368b811fdeee203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute-Phase Proteins - analysis</topic><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body Weight</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Cholesterol, Dietary - pharmacology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Serum Amyloid A Protein - analysis</topic><topic>Thinness</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TANNOCK, Lisa R</creatorcontrib><creatorcontrib>O'BRIEN, Kevin D</creatorcontrib><creatorcontrib>KNOPP, Robert H</creatorcontrib><creatorcontrib>RETZLAFF, Barbara</creatorcontrib><creatorcontrib>FISH, Brian</creatorcontrib><creatorcontrib>WENER, Mark H</creatorcontrib><creatorcontrib>KAHN, Steven E</creatorcontrib><creatorcontrib>CHAIT, Alan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANNOCK, Lisa R</au><au>O'BRIEN, Kevin D</au><au>KNOPP, Robert H</au><au>RETZLAFF, Barbara</au><au>FISH, Brian</au><au>WENER, Mark H</au><au>KAHN, Steven E</au><au>CHAIT, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2005-06-14</date><risdate>2005</risdate><volume>111</volume><issue>23</issue><spage>3058</spage><epage>3062</epage><pages>3058-3062</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known.
C-reactive protein (CRP), serum amyloid A (SAA), and lipoprotein levels were compared in 201 healthy subjects on an American Heart Association-National Cholesterol Education Program step 1 diet at baseline and after addition of 4 eggs per day for 4 weeks. Subjects were classified a priori into 3 groups based on their body mass index (BMI) and insulin sensitivity index (SI): lean insulin sensitive (LIS), mean+/-SEM BMI, 23.2+/-0.3 kg/m2, and SI, 6.7+/-0.3x10(-4)min(-1)/(microU/mL), n=66; lean insulin resistant (LIR), BMI, 24.5+/-0.2 kg/m2 and SI, 2.9+/-0.1x10(-4)min(-1)/(microU/mL), n=76; or obese insulin resistant (OIR), BMI, 31.4+/-0.5 kg/m2 and SI, 2.1+/-0.1x10(-4)min(-1)/(microU/mL), n=59. Insulin resistance and obesity each were associated with increased baseline levels of both CRP (P for trend, <0.001) and SAA (P for trend=0.015). Egg feeding was associated with significant increases in both CRP and SAA in the LIS group (both P<0.01) but not in the LIR or OIR groups. Egg feeding also was associated with a significant increase in non-HDL cholesterol (P<0.001) in LIS subjects; however, there was no correlation between the change in non-HDL cholesterol or changes in either CRP or SAA in this group.
A high-cholesterol diet leads to significant increases in both inflammatory markers and non-HDL cholesterol levels in insulin-sensitive individuals but not in lean or obese insulin-resistant subjects.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15939816</pmid><doi>10.1161/CIRCULATIONAHA.104.506188</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Ovid Autoload; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute-Phase Proteins - analysis Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Body Weight C-Reactive Protein - analysis Cardiology. Vascular system Cholesterol, Dietary - administration & dosage Cholesterol, Dietary - pharmacology Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Inflammation Insulin Resistance Male Medical sciences Middle Aged Obesity Serum Amyloid A Protein - analysis Thinness Up-Regulation - drug effects |
| title | Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects |
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