Tricaprylin microemulsion for oral delivery of low molecular weight heparin conjugates

Heparin is available to patients only by parenteral administrations due to its low oral bioavailability. For the oral delivery of low molecular weight heparin (LMWH), LMWH–DOCA was synthesized by chemical conjugation of LMWH and deoxycholic acid (DOCA) and this conjugate was formulated in a microemu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of controlled release 2005-06, Vol.105 (1), p.32-42
Hauptverfasser:	Kim, Sang Kyoon, Lee, Eun Hye, Vaishali, Bagalkot, Lee, Seulki, Lee, Yong-kyu, Kim, Choong-Yong, Moon, Hyun Tae, Byun, Youngro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anticoagulants - administration & dosage Anticoagulants - chemistry Anticoagulants - pharmacokinetics Area Under Curve Biological and medical sciences Caprylates - chemistry Chemistry, Pharmaceutical Deoxycholic acid Desoxycorticosterone Emulsions Excipients General pharmacology Half-Life Heparin, Low-Molecular-Weight - administration & dosage Heparin, Low-Molecular-Weight - chemistry Heparin, Low-Molecular-Weight - pharmacokinetics Intestinal Absorption - drug effects Low molecule weight heparin Macaca fascicularis Medical sciences Mice Mice, Inbred ICR Microemulsion Molecular Weight Oils - chemistry Oils - pharmacology Oral delivery Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polysorbates Solubility Sorbitol Tricaprylin Triglycerides - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!