Synthesis and Receptor Binding Evaluation of Clavizepine Analogues with No Ring D Substituents
Assembly of the azepine ring of xantheno[9,1-cd]azepines by electrophilic cyclization of sulfonamide acetals provides access to clavizepine analogues in the form of 2,12b-dihydro- or 4-hydroxy-2,3,4,12b-tetrahydro-1H-xantheno[9,1-cd]azepines, in the latter case producing the trans derivative stereos...
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| Veröffentlicht in: | Journal of organic chemistry 2006-05, Vol.71 (10), p.3963-3966 |
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| container_end_page | 3966 |
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| container_issue | 10 |
| container_start_page | 3963 |
| container_title | Journal of organic chemistry |
| container_volume | 71 |
| creator | de la Fuente, M. Carmen Pullan, Shirley E Biesmans, Ilse Domínguez, Domingo |
| description | Assembly of the azepine ring of xantheno[9,1-cd]azepines by electrophilic cyclization of sulfonamide acetals provides access to clavizepine analogues in the form of 2,12b-dihydro- or 4-hydroxy-2,3,4,12b-tetrahydro-1H-xantheno[9,1-cd]azepines, in the latter case producing the trans derivative stereoselectively. Binding assays for clavizepine and analogues at adrenergic, dopaminergic, and serotonergic receptors are reported. |
| doi_str_mv | 10.1021/jo052320c |
| format | Article |
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| source | ACS Publications; MEDLINE |
| subjects | Azepines - chemistry Chemistry Exact sciences and technology Fumariaceae - chemistry Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Models, Molecular Molecular Structure Organic chemistry Preparations and properties Protein Binding Receptors, Serotonin - chemistry Xanthenes - chemistry |
| title | Synthesis and Receptor Binding Evaluation of Clavizepine Analogues with No Ring D Substituents |
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