Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice

The CTG repeat involved in myotonic dystrophy is one of the most unstable trinucleotide repeats. However, the molecular mechanisms underlying this particular form of genetic instability-biased towards expansions-have not yet been completely elucidated. We previously showed, with highly unstable CTG...

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Veröffentlicht in:	Human genetics 2006-06, Vol.119 (5), p.520-526
Hauptverfasser:	FOIRY, Laurent, LI DONG, SAVOURET, Cédric, HUBERT, Laurence, TE RIELE, Hein, JUNIEN, Claudine, GOURDON, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Pair Mismatch - genetics Biological and medical sciences Classical genetics, quantitative genetics, hybrids DNA polymerase DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glycerol Human Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic MutS Homolog 3 Protein Myotonic Dystrophy - genetics Ovaries Proteins Transgenic animals Trinucleotide Repeat Expansion - genetics Weaning
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