Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Ventricular myocyte hypertrophy is an important compensatory growth response to pressure overload. However, pathophysiological cardiac hypertrophy is accompanied by reactive fibrosis and remodeling. The Rho kinase family, consisting of ROCK1 and ROCK2, has been implicated in cardiac hypertrophy and...

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Veröffentlicht in:	The FASEB journal 2006-05, Vol.20 (7), p.916-925
Hauptverfasser:	Zhang, Ying-Min, Bo, Jacqueline, Taffet, George E, Chang, Jiang, Shi, Jianjian, Reddy, Anilkumar K, Michael, Lloyd H, Schneider, Michael D, Entman, Mark L, Schwartz, Robert J, Wei, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - physiopathology fibrogenic cytokines fibrosis Fibrosis - metabolism Fibrosis - pathology Fibrosis - prevention & control Gene Expression Regulation, Enzymologic Genotype Heart - physiology Heart - physiopathology hypertrophy Intracellular Signaling Peptides and Proteins Mice Mice, Knockout Phenotype Pressure pressure overload Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Rho kinase rho-Associated Kinases Ventricular Remodeling - physiology
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