Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis
To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). Prospective, nonrandomized comparative clinical trial. Seventy eyes of 35 patients and 76 e...
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| Veröffentlicht in: | American journal of ophthalmology 2005-06, Vol.139 (6), p.965-971 |
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| creator | Lee, Hyung Keun Lee, Kyung Sub Kim, Hyeon Chang Lee, Sung Ho Kim, Eung Kweon |
| description | To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
Prospective, nonrandomized comparative clinical trial.
Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, tear film breakup time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery.
The postoperative mean tear NGF/total tear protein (NGF/tP) ratio increased in both PRK and LASIK patients compared with preoperative levels (
P < .0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (
P < .0001). Before 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (
P < .0001), but this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared with PRK-treated eyes up to 6 months postoperatively (
P < .0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6-month value of corneal sensation, BUT, and Schirmer values.
The difference in the postoperative corneal sensation and ocular surface dryness between PRK-treated and LASIK-treated eyes might be related to the difference in the early postoperative levels of NGF, which is a potent nerve growth stimulator. |
| doi_str_mv | 10.1016/j.ajo.2004.12.051 |
| format | Article |
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Prospective, nonrandomized comparative clinical trial.
Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, tear film breakup time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery.
The postoperative mean tear NGF/total tear protein (NGF/tP) ratio increased in both PRK and LASIK patients compared with preoperative levels (
P < .0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (
P < .0001). Before 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (
P < .0001), but this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared with PRK-treated eyes up to 6 months postoperatively (
P < .0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6-month value of corneal sensation, BUT, and Schirmer values.
The difference in the postoperative corneal sensation and ocular surface dryness between PRK-treated and LASIK-treated eyes might be related to the difference in the early postoperative levels of NGF, which is a potent nerve growth stimulator.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2004.12.051</identifier><identifier>PMID: 15953424</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Astigmatism - surgery ; Biological and medical sciences ; Cornea - physiology ; Cornea - surgery ; Corneal Diseases - etiology ; Corneal Diseases - metabolism ; Diabetic retinopathy ; Dry Eye Syndromes - etiology ; Dry Eye Syndromes - metabolism ; Enzyme-Linked Immunosorbent Assay ; Eye Proteins - metabolism ; Female ; Humans ; Keratomileusis, Laser In Situ - adverse effects ; Lasers ; Lasers, Excimer ; Male ; Medical sciences ; Miscellaneous ; Myopia - surgery ; Nerve Growth Factor - metabolism ; Ophthalmology ; Photorefractive Keratectomy - adverse effects ; Polyesters ; Prospective Studies ; Sensation - physiology ; Surgery ; Tears - metabolism</subject><ispartof>American journal of ophthalmology, 2005-06, Vol.139 (6), p.965-971</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-b2454df46d582ef807e693ad05bf3a5b28d8ee81f3124385710b700c56d8d1bd3</citedby><cites>FETCH-LOGICAL-c475t-b2454df46d582ef807e693ad05bf3a5b28d8ee81f3124385710b700c56d8d1bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939404015946$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16930373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15953424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Hyung Keun</creatorcontrib><creatorcontrib>Lee, Kyung Sub</creatorcontrib><creatorcontrib>Kim, Hyeon Chang</creatorcontrib><creatorcontrib>Lee, Sung Ho</creatorcontrib><creatorcontrib>Kim, Eung Kweon</creatorcontrib><title>Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
Prospective, nonrandomized comparative clinical trial.
Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, tear film breakup time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery.
The postoperative mean tear NGF/total tear protein (NGF/tP) ratio increased in both PRK and LASIK patients compared with preoperative levels (
P < .0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (
P < .0001). Before 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (
P < .0001), but this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared with PRK-treated eyes up to 6 months postoperatively (
P < .0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6-month value of corneal sensation, BUT, and Schirmer values.
The difference in the postoperative corneal sensation and ocular surface dryness between PRK-treated and LASIK-treated eyes might be related to the difference in the early postoperative levels of NGF, which is a potent nerve growth stimulator.</description><subject>Adult</subject><subject>Astigmatism - surgery</subject><subject>Biological and medical sciences</subject><subject>Cornea - physiology</subject><subject>Cornea - surgery</subject><subject>Corneal Diseases - etiology</subject><subject>Corneal Diseases - metabolism</subject><subject>Diabetic retinopathy</subject><subject>Dry Eye Syndromes - etiology</subject><subject>Dry Eye Syndromes - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Eye Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Keratomileusis, Laser In Situ - adverse effects</subject><subject>Lasers</subject><subject>Lasers, Excimer</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Myopia - surgery</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Ophthalmology</subject><subject>Photorefractive Keratectomy - adverse effects</subject><subject>Polyesters</subject><subject>Prospective Studies</subject><subject>Sensation - physiology</subject><subject>Surgery</subject><subject>Tears - metabolism</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGLFDEQhYMo7rj6A7xIQPTWbdJJOgmelsFdBwcV1HNIJ9Vsmu7ObNI9sv_erDOw4MFTUdT3iqr3EHpNSU0JbT8MtR1i3RDCa9rURNAnaEOV1BVVmj5FG0JIU2mm-QV6kfNQ2lZy-RxdUKEF4w3foLuvkI6Ab1L8vdzia-uWmPA2zg7mJdklxBnb2ePddBiD-9tnHGb8_TYWEPpUBKHov0CBoYine3zMeG8zJLyb8Y-wrKdhnMIIaw75JXrW2zHDq3O9RL-uP_3cfq72325226t95bgUS9U1XHDf89YL1UCviIRWM-uJ6HpmRdcorwAU7RltOFNCUtJJQpxovfK08-wSvT_tPaR4t0JezBSyg3G0M8Q1m1ZqRqRUBXz7DzjENc3lNkNbzpXWnOlC0RPlUsy5vG4OKUw23RtKzEMaZjAlDfOQhqGNKWkUzZvz5rWbwD8qzvYX4N0ZsNnZsdg5u5AfufIxYZIV7uOJg2LYMUAy2QUoIfmQiuvGx_CfM_4AMhWn_Q</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Lee, Hyung Keun</creator><creator>Lee, Kyung Sub</creator><creator>Kim, Hyeon Chang</creator><creator>Lee, Sung Ho</creator><creator>Kim, Eung Kweon</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis</title><author>Lee, Hyung Keun ; Lee, Kyung Sub ; Kim, Hyeon Chang ; Lee, Sung Ho ; Kim, Eung Kweon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-b2454df46d582ef807e693ad05bf3a5b28d8ee81f3124385710b700c56d8d1bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Astigmatism - surgery</topic><topic>Biological and medical sciences</topic><topic>Cornea - physiology</topic><topic>Cornea - surgery</topic><topic>Corneal Diseases - etiology</topic><topic>Corneal Diseases - metabolism</topic><topic>Diabetic retinopathy</topic><topic>Dry Eye Syndromes - etiology</topic><topic>Dry Eye Syndromes - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Eye Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Keratomileusis, Laser In Situ - adverse effects</topic><topic>Lasers</topic><topic>Lasers, Excimer</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Myopia - surgery</topic><topic>Nerve Growth Factor - metabolism</topic><topic>Ophthalmology</topic><topic>Photorefractive Keratectomy - adverse effects</topic><topic>Polyesters</topic><topic>Prospective Studies</topic><topic>Sensation - physiology</topic><topic>Surgery</topic><topic>Tears - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Hyung Keun</creatorcontrib><creatorcontrib>Lee, Kyung Sub</creatorcontrib><creatorcontrib>Kim, Hyeon Chang</creatorcontrib><creatorcontrib>Lee, Sung Ho</creatorcontrib><creatorcontrib>Kim, Eung Kweon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Hyung Keun</au><au>Lee, Kyung Sub</au><au>Kim, Hyeon Chang</au><au>Lee, Sung Ho</au><au>Kim, Eung Kweon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>139</volume><issue>6</issue><spage>965</spage><epage>971</epage><pages>965-971</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To determine whether tear nerve growth factor (NGF) concentration correlates with corneal sensation and ocular surface dryness after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
Prospective, nonrandomized comparative clinical trial.
Seventy eyes of 35 patients and 76 eyes of 38 patients underwent PRK and LASIK procedures to correct myopia and myopic astigmatism, respectively. Total tear protein level, tear NGF concentration, tear film breakup time (BUT) and Schirmer values were measured before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery.
The postoperative mean tear NGF/total tear protein (NGF/tP) ratio increased in both PRK and LASIK patients compared with preoperative levels (
P < .0001). At 1 week and 1 month postoperatively, the NGF/tP ratio was higher in PRK than in LASIK subjects (
P < .0001). Before 6 months postoperatively, the mean corneal sensation after LASIK in the ablated zone was lower than the preoperative sensation (
P < .0001), but this was not the case in PRK subjects. Mean BUT and Schirmer values were significantly lower in LASIK-treated eyes compared with PRK-treated eyes up to 6 months postoperatively (
P < .0001). The early postoperative tear NGF/tP ratio correlated with the postoperative 6-month value of corneal sensation, BUT, and Schirmer values.
The difference in the postoperative corneal sensation and ocular surface dryness between PRK-treated and LASIK-treated eyes might be related to the difference in the early postoperative levels of NGF, which is a potent nerve growth stimulator.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15953424</pmid><doi>10.1016/j.ajo.2004.12.051</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 2005-06, Vol.139 (6), p.965-971 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Astigmatism - surgery Biological and medical sciences Cornea - physiology Cornea - surgery Corneal Diseases - etiology Corneal Diseases - metabolism Diabetic retinopathy Dry Eye Syndromes - etiology Dry Eye Syndromes - metabolism Enzyme-Linked Immunosorbent Assay Eye Proteins - metabolism Female Humans Keratomileusis, Laser In Situ - adverse effects Lasers Lasers, Excimer Male Medical sciences Miscellaneous Myopia - surgery Nerve Growth Factor - metabolism Ophthalmology Photorefractive Keratectomy - adverse effects Polyesters Prospective Studies Sensation - physiology Surgery Tears - metabolism |
| title | Nerve Growth Factor Concentration and Implications in Photorefractive Keratectomy vs Laser In Situ Keratomileusis |
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