NOD-LRR proteins: role in host-microbial interactions and inflammatory disease
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic var...
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| Veröffentlicht in: | Annual review of biochemistry 2005-01, Vol.74 (1), p.355-383 |
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| creator | Inohara Chamaillard McDonald, Christine Nuñez, Gabriel |
| description | Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections. Nod1, Nod2, Cryopyrin, and Ipaf have been implicated in protective immune responses against pathogens. Together with Toll-like receptors, Nod1 and Nod2 appear to play important roles in innate and acquired immunity as sensors of bacterial components. Specifically, Nod1 and Nod2 participate in the signaling events triggered by host recognition of specific motifs in bacterial peptidoglycan and, upon activation, induce the production of proinflammatory mediators. Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanisms, whereas CIITA plays a critical role in antigen presentation and development of antigen-specific T lymphocytes. Thus, NOD-LRR proteins appear to be involved in a diverse array of processes required for host immune reactions against pathogens. |
| doi_str_mv | 10.1146/annurev.biochem.74.082803.133347 |
| format | Article |
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These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections. Nod1, Nod2, Cryopyrin, and Ipaf have been implicated in protective immune responses against pathogens. Together with Toll-like receptors, Nod1 and Nod2 appear to play important roles in innate and acquired immunity as sensors of bacterial components. Specifically, Nod1 and Nod2 participate in the signaling events triggered by host recognition of specific motifs in bacterial peptidoglycan and, upon activation, induce the production of proinflammatory mediators. Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanisms, whereas CIITA plays a critical role in antigen presentation and development of antigen-specific T lymphocytes. Thus, NOD-LRR proteins appear to be involved in a diverse array of processes required for host immune reactions against pathogens.</description><identifier>ISSN: 0066-4154</identifier><identifier>EISSN: 1545-4509</identifier><identifier>DOI: 10.1146/annurev.biochem.74.082803.133347</identifier><identifier>PMID: 15952891</identifier><identifier>CODEN: ARBOAW</identifier><language>eng</language><publisher>United States: Annual Reviews, Inc</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - immunology ; Adaptor Proteins, Signal Transducing - metabolism ; Animals ; Crohn's disease ; Genetic diversity ; Genetics ; Humans ; Immune system ; Infection - genetics ; Infection - immunology ; Infection - microbiology ; Inflammation - genetics ; Inflammation - immunology ; Inflammation - microbiology ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - immunology ; Intracellular Signaling Peptides and Proteins - metabolism ; Legionella pneumophila ; Ligands ; Lymphocytes ; Models, Molecular ; Mutation ; Nod1 Signaling Adaptor Protein ; Nod2 Signaling Adaptor Protein ; Pathogens ; Plants - immunology ; Protein Structure, Tertiary ; Proteins ; Signal Transduction</subject><ispartof>Annual review of biochemistry, 2005-01, Vol.74 (1), p.355-383</ispartof><rights>Copyright Annual Reviews, Inc. 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-68322753bbf35505a1a106c86980753014f32a6ed1e71d42c21119da5a707fce3</citedby><cites>FETCH-LOGICAL-c516t-68322753bbf35505a1a106c86980753014f32a6ed1e71d42c21119da5a707fce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4182,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15952891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inohara</creatorcontrib><creatorcontrib>Chamaillard</creatorcontrib><creatorcontrib>McDonald, Christine</creatorcontrib><creatorcontrib>Nuñez, Gabriel</creatorcontrib><title>NOD-LRR proteins: role in host-microbial interactions and inflammatory disease</title><title>Annual review of biochemistry</title><addtitle>Annu Rev Biochem</addtitle><description>Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections. Nod1, Nod2, Cryopyrin, and Ipaf have been implicated in protective immune responses against pathogens. Together with Toll-like receptors, Nod1 and Nod2 appear to play important roles in innate and acquired immunity as sensors of bacterial components. Specifically, Nod1 and Nod2 participate in the signaling events triggered by host recognition of specific motifs in bacterial peptidoglycan and, upon activation, induce the production of proinflammatory mediators. Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanisms, whereas CIITA plays a critical role in antigen presentation and development of antigen-specific T lymphocytes. Thus, NOD-LRR proteins appear to be involved in a diverse array of processes required for host immune reactions against pathogens.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - immunology</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animals</subject><subject>Crohn's disease</subject><subject>Genetic diversity</subject><subject>Genetics</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infection - genetics</subject><subject>Infection - immunology</subject><subject>Infection - microbiology</subject><subject>Inflammation - genetics</subject><subject>Inflammation - immunology</subject><subject>Inflammation - microbiology</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - immunology</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Legionella pneumophila</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Models, Molecular</subject><subject>Mutation</subject><subject>Nod1 Signaling Adaptor Protein</subject><subject>Nod2 Signaling Adaptor Protein</subject><subject>Pathogens</subject><subject>Plants - 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Academic</collection><jtitle>Annual review of biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inohara</au><au>Chamaillard</au><au>McDonald, Christine</au><au>Nuñez, Gabriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NOD-LRR proteins: role in host-microbial interactions and inflammatory disease</atitle><jtitle>Annual review of biochemistry</jtitle><addtitle>Annu Rev Biochem</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>74</volume><issue>1</issue><spage>355</spage><epage>383</epage><pages>355-383</pages><issn>0066-4154</issn><eissn>1545-4509</eissn><coden>ARBOAW</coden><abstract>Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins. Genetic variation in several NOD-LRR proteins, including human Nod2, Cryopyrin, and CIITA, as well as mouse Naip5, is associated with inflammatory disease or increased susceptibility to microbial infections. Nod1, Nod2, Cryopyrin, and Ipaf have been implicated in protective immune responses against pathogens. Together with Toll-like receptors, Nod1 and Nod2 appear to play important roles in innate and acquired immunity as sensors of bacterial components. Specifically, Nod1 and Nod2 participate in the signaling events triggered by host recognition of specific motifs in bacterial peptidoglycan and, upon activation, induce the production of proinflammatory mediators. Naip5 is involved in host resistance to Legionella pneumophila through cell autonomous mechanisms, whereas CIITA plays a critical role in antigen presentation and development of antigen-specific T lymphocytes. Thus, NOD-LRR proteins appear to be involved in a diverse array of processes required for host immune reactions against pathogens.</abstract><cop>United States</cop><pub>Annual Reviews, Inc</pub><pmid>15952891</pmid><doi>10.1146/annurev.biochem.74.082803.133347</doi><tpages>29</tpages></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Animals Crohn's disease Genetic diversity Genetics Humans Immune system Infection - genetics Infection - immunology Infection - microbiology Inflammation - genetics Inflammation - immunology Inflammation - microbiology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism Legionella pneumophila Ligands Lymphocytes Models, Molecular Mutation Nod1 Signaling Adaptor Protein Nod2 Signaling Adaptor Protein Pathogens Plants - immunology Protein Structure, Tertiary Proteins Signal Transduction |
| title | NOD-LRR proteins: role in host-microbial interactions and inflammatory disease |
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