Novel matrix metalloproteinase inhibitors: Generation of lead compounds by the in silico fragment-based approach

Discovery process of a new chemical lead to identify matrix metalloproteinase inhibitors using the in silico fragment-based approach is reported. Generation of structurally new matrix metalloproteinase inhibitors was successfully carried out using an in silico technique. In order to identify the sma...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-07, Vol.13 (14), p.4527-4543
Hauptverfasser:	Takahashi, Kanji, Ikura, Masahiro, Habashita, Hiromu, Nishizaki, Minoru, Sugiura, Tsuneyuki, Yamamoto, Shingo, Nakatani, Shingo, Ogawa, Koji, Ohno, Hiroyuki, Nakai, Hisao, Toda, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Magnetic Resonance Spectroscopy Matrix Metalloproteinase Inhibitors Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Spectrometry, Mass, Fast Atom Bombardment Structure-Activity Relationship
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