Structural insights into translational fidelity

The underlying basis for the accuracy of protein synthesis has been the subject of over four decades of investigation. Recent biochemical and structural data make it possible to understand at least in outline the structural basis for tRNA selection, in which codon recognition by cognate tRNA results...

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Veröffentlicht in:	Annual review of biochemistry 2005-01, Vol.74 (1), p.129-177
Hauptverfasser:	Ogle, James M, Ramakrishnan, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Anti-Bacterial Agents - pharmacology Antibiotics Base Pairing Biochemistry Cryoelectron Microscopy Crystallography Crystallography, X-Ray Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Hydrolysis Kinetics Models, Genetic Models, Molecular Molecular biology Mutation Protein Biosynthesis - drug effects Protein synthesis Proteins Ribonucleic acid Ribosomes - genetics Ribosomes - metabolism Ribosomes - ultrastructure RNA RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Transfer - chemistry RNA, Transfer - genetics
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