Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors

[Display omitted] Bicyclic analogues of methyllycaconitine (MLA), such as 12, have been synthesised that incorporate the C1–OMe substituent present in the natural product. Electrophysiology experiments using Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) were conducted on thes...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-07, Vol.13 (14), p.4565-4575
Hauptverfasser:	Barker, David, Lin, Diana H.-S., Carland, Jane E., Chu, Cindy P.-Y., Chebib, Mary, Brimble, Margaret A., Savage, G. Paul, McLeod, Malcolm D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - analogs & derivatives Aconitine - pharmacology Animals Biological and medical sciences Cholinergic system Magnetic Resonance Spectroscopy Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nicotinic Antagonists - pharmacology Pharmacology. Drug treatments Receptors, Nicotinic - drug effects Spectrometry, Mass, Electrospray Ionization Xenopus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!