Ischemic Preconditioning: A Novel Target for Neuroprotective Therapy

Ischemic preconditioning involves a brief exposure to ischemia in order to develop a tolerance to injurious effects of prolonged ischemia. The molecular mechanisms of neuroprotection that lead to ischemic tolerance are not yet completely understood. However, it seems that two distinct phases are inv...

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Veröffentlicht in:	Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2006-05, Vol.21 (Suppl 2), p.38-47
Hauptverfasser:	Blanco, Miguel, Lizasoain, Ignacio, Sobrino, Tomás, Vivancos, José, Castillo, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism alpha-Linolenic Acid - pharmacology alpha-Linolenic Acid - therapeutic use Animals Brain - blood supply Brain - drug effects Brain - metabolism Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - therapy Clinical Trials as Topic Cytokines - metabolism Diazoxide - pharmacology Diazoxide - therapeutic use Drug Evaluation, Preclinical Gene Expression Regulation Genes, Immediate-Early Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Ischemic Preconditioning - methods Models, Animal Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Potassium Channels - metabolism Receptors, Glutamate - metabolism Stroke - genetics Stroke - metabolism Stroke - therapy
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