Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats

Portal hypertension is characterized by the development of a hyperdynamic splanchnic circulation. To determine whether this process is angiogenesis-dependent, we assessed the effects of SU5416, a specific inhibitor of VEGF receptor-2, in portal hypertensive rats. Rats with portal hypertension induce...

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Veröffentlicht in:	Journal of hepatology 2005-07, Vol.43 (1), p.98-103
Hauptverfasser:	Fernandez, Mercedes, Mejias, Marc, Angermayr, Bernhard, Garcia-Pagan, Juan Carlos, Rodés, Juan, Bosch, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Arterioles - physiopathology Biological and medical sciences Collateral Circulation - drug effects Gastroenterology. Liver. Pancreas. Abdomen Hemodynamics - drug effects Hyperdynamic splanchnic circulation Hypertension, Portal - complications Hypertension, Portal - physiopathology Indoles - pharmacology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Neovascularization, Pathologic - etiology Other diseases. Semiology Platelet Endothelial Cell Adhesion Molecule-1 - drug effects Portal hypertension Portal System - physiopathology Portal Vein - physiopathology Portal-systemic collateral vessels Protein Kinase Inhibitors - pharmacology Pyrroles - pharmacology Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Splanchnic Circulation - drug effects SU5416 Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Resistance - drug effects
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