Quinoline antimalarials decrease the rate of β-hematin formation

The strength of inhibition of β-hematin (synthetic hemozoin or malaria pigment) formation by the quinoline antimalarial drugs chloroquine, amodiaquine, quinidine and quinine has been investigated as a function of incubation time. In the assay used, β-hematin formation was brought about using 4.5M ac...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of inorganic biochemistry 2005-07, Vol.99 (7), p.1532-1539
Hauptverfasser:	Egan, Timothy J., Ncokazi, Kanyile K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amodiaquine Antimalarials - chemistry Chloroquine Hemeproteins - chemical synthesis Hemeproteins - chemistry Hemozoin Malaria Microscopy, Electron, Scanning Quinidine Quinine Quinolines - chemistry Spectrophotometry, Infrared Time Factors X-Ray Diffraction β-Hematin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!