Cancer therapy: can the challenge be MET?

The deregulation of tyrosine kinase receptors (RTKs) is frequent in human tumors and is often associated with the acquisition of an aggressive phenotype. The Met oncogene, encoding the RTK for hepatocyte growth factor (HGF), controls genetic programs leading to cell growth, invasion and protection f...

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Veröffentlicht in:	Trends in molecular medicine 2005-06, Vol.11 (6), p.284-292
Hauptverfasser:	Corso, Simona, Comoglio, Paolo M., Giordano, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Adhesion Cell Adhesion Molecules - metabolism Hepatocyte Growth Factor - metabolism Humans Hyaluronan Receptors - biosynthesis Hyaluronan Receptors - metabolism Models, Biological Neoplasm Invasiveness Neoplasms - metabolism Neoplasms - therapy Nerve Tissue Proteins - metabolism Phenotype Proto-Oncogene Proteins c-met - physiology Signal Transduction
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