Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection
The Foxp3 protein is a specific marker of CD4+CD25+ regulatory T (Treg) cells, and its expression is critical to their development and function. Several studies have demonstrated the dysregulation of Foxp3 expression during human inflammatory diseases. Infection with human T lymphotropic virus type...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-06, Vol.193 (11), p.1557-1566 |
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| creator | Oh, Unsong Grant, Christian Griffith, Caitlin Fugo, Kazunori Takenouchi, Norihiro Jacobson, Steven |
| description | The Foxp3 protein is a specific marker of CD4+CD25+ regulatory T (Treg) cells, and its expression is critical to their development and function. Several studies have demonstrated the dysregulation of Foxp3 expression during human inflammatory diseases. Infection with human T lymphotropic virus type 1 (HTLV-1) is associated with the development of a number of inflammatory conditions, including myelopathy, although the majority of individuals who are infected with HTLV-1 remain asymptomatic. To examine the role played by Treg cells in the development of inflammatory disease during HTLV-1 infection, we examined Foxp3 expression by flow cytometry. Our analysis showed that HTLV-1–associated myelopathy/tropical spastic paraparesis was associated with a lower expression (compared with that in asymptomatic HTLV-1 carriers and healthy donors) of Foxp3 in peripheral-blood leukocytes. In individuals infected with HTLV-1, Foxp3 expression was inversely correlated with HTLV-1 tax proviral DNA load. These results suggest that impaired Foxp3 expression may contribute to the development of inflammatory disease during HTLV-1 infection |
| doi_str_mv | 10.1086/503874 |
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These results suggest that impaired Foxp3 expression may contribute to the development of inflammatory disease during HTLV-1 infection</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/503874</identifier><identifier>PMID: 16652285</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>B lymphocytes ; Biological and medical sciences ; CD4 Antigens - analysis ; Cell lines ; Cytometry ; DNA, Viral - blood ; Female ; Flow Cytometry ; Forkhead Transcription Factors - biosynthesis ; Fundamental and applied biological sciences. 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Psychology</subject><subject>Genes, pX</subject><subject>HTLV-I Infections - immunology</subject><subject>HTLV-I Infections - metabolism</subject><subject>Human T lymphotropic virus 1</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Messenger RNA</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Monoclonal antibodies</subject><subject>Nervous system diseases</subject><subject>Paraparesis, Tropical Spastic - immunology</subject><subject>Paraparesis, Tropical Spastic - metabolism</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Statistics as Topic</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V2LEzEUBuAgiltX_QdKFPRuNF-Tj8ulu2srRUWrK96ENJNx052ZjMkMtvjnTW3ZgiBe5eI8eUPOC8BjjF5hJPnrElEp2B0wwSUVBeeY3gUThAgpsFTqBDxIaY0QYpSL--AEc14SIssJ-PXRVaN1FbwMm57CDzEMznfwYtNHl5IPHZwneJZSsN4Mmf30wzWcd3Vj2tYMIW7huU_OJAerMfruO5yNrengEi62bX8dhhh6b-EXH8cEl9veQby77eyQox-Ce7Vpknt0OE_B58uL5XRWLN6_mU_PFoVlkg4FtqiUuFKsriytasYodtaupDJYIsaVrDiqLHFCGIEFV24lSisll4zalWKKnoKX-9w-hh-jS4NufbKuaUznwpg0F4pwlPn_IFZKEIFphs__guswxi5_QhNCFcKCoWOajSGl6GrdR9-auNUY6V1pel9ahk8PaeOqddWRHVrK4MUBmGRNU0fTWZ-OTqi8IbILerZ3Yez__diTvVmnXN-toigb_udrxX7u0-A2t3MTb_KeqCj17Os3Ta-m55_eXb3VM_ob9XXAKw</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Oh, Unsong</creator><creator>Grant, Christian</creator><creator>Griffith, Caitlin</creator><creator>Fugo, Kazunori</creator><creator>Takenouchi, Norihiro</creator><creator>Jacobson, Steven</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection</title><author>Oh, Unsong ; Grant, Christian ; Griffith, Caitlin ; Fugo, Kazunori ; Takenouchi, Norihiro ; Jacobson, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-1c0581d94fdc3df4431eccb89a1804698d60dc2e77a71769eb75c886843cb9493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens - analysis</topic><topic>Cell lines</topic><topic>Cytometry</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Forkhead Transcription Factors - biosynthesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, pX</topic><topic>HTLV-I Infections - immunology</topic><topic>HTLV-I Infections - metabolism</topic><topic>Human T lymphotropic virus 1</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Messenger RNA</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Monoclonal antibodies</topic><topic>Nervous system diseases</topic><topic>Paraparesis, Tropical Spastic - immunology</topic><topic>Paraparesis, Tropical Spastic - metabolism</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Statistics as Topic</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis</topic><topic>Viral Load</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Unsong</creatorcontrib><creatorcontrib>Grant, Christian</creatorcontrib><creatorcontrib>Griffith, Caitlin</creatorcontrib><creatorcontrib>Fugo, Kazunori</creatorcontrib><creatorcontrib>Takenouchi, Norihiro</creatorcontrib><creatorcontrib>Jacobson, Steven</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Unsong</au><au>Grant, Christian</au><au>Griffith, Caitlin</au><au>Fugo, Kazunori</au><au>Takenouchi, Norihiro</au><au>Jacobson, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>193</volume><issue>11</issue><spage>1557</spage><epage>1566</epage><pages>1557-1566</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The Foxp3 protein is a specific marker of CD4+CD25+ regulatory T (Treg) cells, and its expression is critical to their development and function. Several studies have demonstrated the dysregulation of Foxp3 expression during human inflammatory diseases. Infection with human T lymphotropic virus type 1 (HTLV-1) is associated with the development of a number of inflammatory conditions, including myelopathy, although the majority of individuals who are infected with HTLV-1 remain asymptomatic. To examine the role played by Treg cells in the development of inflammatory disease during HTLV-1 infection, we examined Foxp3 expression by flow cytometry. Our analysis showed that HTLV-1–associated myelopathy/tropical spastic paraparesis was associated with a lower expression (compared with that in asymptomatic HTLV-1 carriers and healthy donors) of Foxp3 in peripheral-blood leukocytes. In individuals infected with HTLV-1, Foxp3 expression was inversely correlated with HTLV-1 tax proviral DNA load. These results suggest that impaired Foxp3 expression may contribute to the development of inflammatory disease during HTLV-1 infection</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16652285</pmid><doi>10.1086/503874</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | B lymphocytes Biological and medical sciences CD4 Antigens - analysis Cell lines Cytometry DNA, Viral - blood Female Flow Cytometry Forkhead Transcription Factors - biosynthesis Fundamental and applied biological sciences. Psychology Genes, pX HTLV-I Infections - immunology HTLV-I Infections - metabolism Human T lymphotropic virus 1 Humans Infections Infectious diseases Lymphocyte Subsets - immunology Male Medical sciences Messenger RNA Microbiology Middle Aged Miscellaneous Monoclonal antibodies Nervous system diseases Paraparesis, Tropical Spastic - immunology Paraparesis, Tropical Spastic - metabolism Receptors, Interleukin-2 - analysis Statistics as Topic T lymphocytes T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 - analysis Viral Load Virology Viruses |
| title | Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection |
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