Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial
Although peripheral fat loss is a consistent feature of HIV-associated lipodystrophy, less is known about whether changes in central and peripheral fat occur in tandem or independently over time. We examined intraindividual changes in dual-energy x-ray absorptiometry (DEXA) and anthropometry data ov...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2006-04, Vol.41 (5), p.590-597 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | MULLIGAN, Kathleen PARKER, Robert A KOMAROW, Lauren GRINSPOON, Steven K TEBAS, Pablo ROBBINS, Gregory K ROUBENOFF, Ronenn DUBE, Michael P |
| description | Although peripheral fat loss is a consistent feature of HIV-associated lipodystrophy, less is known about whether changes in central and peripheral fat occur in tandem or independently over time. We examined intraindividual changes in dual-energy x-ray absorptiometry (DEXA) and anthropometry data over 64 weeks after initiation of antiretroviral therapy (ART).
In ACTG 384, ART-naive subjects were randomized to receive didanosine and stavudine or zidovudine and lamivudine plus efavirenz, nelfinavir, or both. In the metabolic substudy A5005S (N= 329), waist, hip, thigh, and arm circumferences were measured in triplicate. DEXA scanning was performed in 157 subjects.
Individual changes in limb and trunk fat at week 64 correlated positively (R =.72, P |
| doi_str_mv | 10.1097/01.qai.0000214811.72916.67 |
| format | Article |
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In ACTG 384, ART-naive subjects were randomized to receive didanosine and stavudine or zidovudine and lamivudine plus efavirenz, nelfinavir, or both. In the metabolic substudy A5005S (N= 329), waist, hip, thigh, and arm circumferences were measured in triplicate. DEXA scanning was performed in 157 subjects.
Individual changes in limb and trunk fat at week 64 correlated positively (R =.72, P <.001). Most subjects had directionally concordant changes in limb and trunk fat (36% gained and 32% lost in both regions). In 26%, trunk fat increased while limb fat decreased, whereas the reverse occurred in only 6% (P <.001). Changes in waist and hip circumferences also correlated positively (R =.62, P <.001). The proportion of subjects with waist/hip ratio more than .95 (men) or .90 (women) was 34% at baseline and 47% at week 64 (P =.003). In those who developed increased waist/hip ratio, 76% had increased waist circumference.
Individual results obtained by both anthropometry and DEXA show diverse patterns of fat gain and loss over 64 weeks after initiation of ART, but changes tended to occur in the same direction. Increased waist/hip ratio was predominantly associated with increased waist circumference. There was no evidence that central fat accumulation and peripheral fat loss are linked in most subjects.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/01.qai.0000214811.72916.67</identifier><identifier>PMID: 16652032</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - drug effects ; Adipose Tissue - pathology ; Adult ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Antiretroviral drugs ; Biological and medical sciences ; Body fat ; Body Size ; Body Weight ; Clinical trials ; Drug therapy ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Infections - drug therapy ; HIV Infections - pathology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Regression Analysis ; Viral diseases ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2006-04, Vol.41 (5), p.590-597</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Apr 15, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-608a84e38a9093b63888c1869c08fd7e4d1869407223a4b9e2a10863e26345423</citedby><cites>FETCH-LOGICAL-c457t-608a84e38a9093b63888c1869c08fd7e4d1869407223a4b9e2a10863e26345423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17701345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16652032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MULLIGAN, Kathleen</creatorcontrib><creatorcontrib>PARKER, Robert A</creatorcontrib><creatorcontrib>KOMAROW, Lauren</creatorcontrib><creatorcontrib>GRINSPOON, Steven K</creatorcontrib><creatorcontrib>TEBAS, Pablo</creatorcontrib><creatorcontrib>ROBBINS, Gregory K</creatorcontrib><creatorcontrib>ROUBENOFF, Ronenn</creatorcontrib><creatorcontrib>DUBE, Michael P</creatorcontrib><title>Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>Although peripheral fat loss is a consistent feature of HIV-associated lipodystrophy, less is known about whether changes in central and peripheral fat occur in tandem or independently over time. We examined intraindividual changes in dual-energy x-ray absorptiometry (DEXA) and anthropometry data over 64 weeks after initiation of antiretroviral therapy (ART).
In ACTG 384, ART-naive subjects were randomized to receive didanosine and stavudine or zidovudine and lamivudine plus efavirenz, nelfinavir, or both. In the metabolic substudy A5005S (N= 329), waist, hip, thigh, and arm circumferences were measured in triplicate. DEXA scanning was performed in 157 subjects.
Individual changes in limb and trunk fat at week 64 correlated positively (R =.72, P <.001). Most subjects had directionally concordant changes in limb and trunk fat (36% gained and 32% lost in both regions). In 26%, trunk fat increased while limb fat decreased, whereas the reverse occurred in only 6% (P <.001). Changes in waist and hip circumferences also correlated positively (R =.62, P <.001). The proportion of subjects with waist/hip ratio more than .95 (men) or .90 (women) was 34% at baseline and 47% at week 64 (P =.003). In those who developed increased waist/hip ratio, 76% had increased waist circumference.
Individual results obtained by both anthropometry and DEXA show diverse patterns of fat gain and loss over 64 weeks after initiation of ART, but changes tended to occur in the same direction. Increased waist/hip ratio was predominantly associated with increased waist circumference. There was no evidence that central fat accumulation and peripheral fat loss are linked in most subjects.</description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - pathology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral drugs</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Size</subject><subject>Body Weight</subject><subject>Clinical trials</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - pathology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Regression Analysis</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFTEQhoMotlb_giwFvds1k2Tz4Z0Uv6DijV6HOTnZNmVPsk1yqhV_vFl74IA35iYZeN53ZvIScg50AGrUGwrDLYaBtsNAaIBBMQNykOoROQUjRK-0Fo_be2RjL4CPJ-RZKTeUghTCPCUnIOXIKGen5PeX8NNvuwVr9TmWLk2du8Z45UsXYud8rBnnDmNDfA7LtV_LCWs3pXlOP0K8alyoAWtIcVVjrCH7mtNdWNG6Kpb71Qy73HzSLvxqDWsOOD8nTyaci39xuM_I9w_vv1186i-_fvx88e6yd2JUtZdUoxaeazTU8I3kWmsHWhpH9bRVXmzXQlDFGEexMZ4hUC25Z5KLUTB-Rl4_-C453e59qXYXivPzjNGnfbFSGTZq_n-QAeVUcN7A83_Am7TPsS1hGedS0NFAg94-QC6nUrKf7JLDDvO9BWrXJC0F25K0xyTt3yTbQE388tBhv9n57VF6iK4Brw4AFofz1D7XhXLklKLQ1ud_AIBPp04</recordid><startdate>20060415</startdate><enddate>20060415</enddate><creator>MULLIGAN, Kathleen</creator><creator>PARKER, Robert A</creator><creator>KOMAROW, Lauren</creator><creator>GRINSPOON, Steven K</creator><creator>TEBAS, Pablo</creator><creator>ROBBINS, Gregory K</creator><creator>ROUBENOFF, Ronenn</creator><creator>DUBE, Michael P</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20060415</creationdate><title>Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial</title><author>MULLIGAN, Kathleen ; PARKER, Robert A ; KOMAROW, Lauren ; GRINSPOON, Steven K ; TEBAS, Pablo ; ROBBINS, Gregory K ; ROUBENOFF, Ronenn ; DUBE, Michael P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-608a84e38a9093b63888c1869c08fd7e4d1869407223a4b9e2a10863e26345423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - pathology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral drugs</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Size</topic><topic>Body Weight</topic><topic>Clinical trials</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - pathology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Regression Analysis</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MULLIGAN, Kathleen</creatorcontrib><creatorcontrib>PARKER, Robert A</creatorcontrib><creatorcontrib>KOMAROW, Lauren</creatorcontrib><creatorcontrib>GRINSPOON, Steven K</creatorcontrib><creatorcontrib>TEBAS, Pablo</creatorcontrib><creatorcontrib>ROBBINS, Gregory K</creatorcontrib><creatorcontrib>ROUBENOFF, Ronenn</creatorcontrib><creatorcontrib>DUBE, Michael P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MULLIGAN, Kathleen</au><au>PARKER, Robert A</au><au>KOMAROW, Lauren</au><au>GRINSPOON, Steven K</au><au>TEBAS, Pablo</au><au>ROBBINS, Gregory K</au><au>ROUBENOFF, Ronenn</au><au>DUBE, Michael P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2006-04-15</date><risdate>2006</risdate><volume>41</volume><issue>5</issue><spage>590</spage><epage>597</epage><pages>590-597</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>Although peripheral fat loss is a consistent feature of HIV-associated lipodystrophy, less is known about whether changes in central and peripheral fat occur in tandem or independently over time. We examined intraindividual changes in dual-energy x-ray absorptiometry (DEXA) and anthropometry data over 64 weeks after initiation of antiretroviral therapy (ART).
In ACTG 384, ART-naive subjects were randomized to receive didanosine and stavudine or zidovudine and lamivudine plus efavirenz, nelfinavir, or both. In the metabolic substudy A5005S (N= 329), waist, hip, thigh, and arm circumferences were measured in triplicate. DEXA scanning was performed in 157 subjects.
Individual changes in limb and trunk fat at week 64 correlated positively (R =.72, P <.001). Most subjects had directionally concordant changes in limb and trunk fat (36% gained and 32% lost in both regions). In 26%, trunk fat increased while limb fat decreased, whereas the reverse occurred in only 6% (P <.001). Changes in waist and hip circumferences also correlated positively (R =.62, P <.001). The proportion of subjects with waist/hip ratio more than .95 (men) or .90 (women) was 34% at baseline and 47% at week 64 (P =.003). In those who developed increased waist/hip ratio, 76% had increased waist circumference.
Individual results obtained by both anthropometry and DEXA show diverse patterns of fat gain and loss over 64 weeks after initiation of ART, but changes tended to occur in the same direction. Increased waist/hip ratio was predominantly associated with increased waist circumference. There was no evidence that central fat accumulation and peripheral fat loss are linked in most subjects.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16652032</pmid><doi>10.1097/01.qai.0000214811.72916.67</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2006-04, Vol.41 (5), p.590-597 |
| issn | 1525-4135 1944-7884 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; World Web Journals; Journals@Ovid Complete |
| subjects | Absorptiometry, Photon Adipose Tissue - drug effects Adipose Tissue - pathology Adult AIDS/HIV Anti-HIV Agents - therapeutic use Antiretroviral drugs Biological and medical sciences Body fat Body Size Body Weight Clinical trials Drug therapy Female Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - pathology Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Miscellaneous Regression Analysis Viral diseases Virology |
| title | Mixed patterns of changes in central and peripheral fat following initiation of antiretroviral therapy in a randomized trial |
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