Lack of apoptosis of Sézary cells in the circulation following oral bexarotene therapy

Summary Background Apoptosis of malignant cells has been suggested as an important mechanism of the action of bexarotene in the treatment of cutaneous T‐cell lymphoma (CTCL). Objectives Our purpose was to examine the in vivo and in vitro responses of patients with Sézary syndrome treated with oral...

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Veröffentlicht in:	British journal of dermatology (1951) 2005-06, Vol.152 (6), p.1199-1205
Hauptverfasser:	Brennand, S., Sutton, V.R., Biagi, J., Trapani, J.A., Westerman, D., McCormack, C.J., Seymour, J.F., Kennedy, G., Prince, H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Anticarcinogenic Agents - therapeutic use Apoptosis bexarotene Biological and medical sciences cutaneous T-cell lymphoma Female Hematologic and hematopoietic diseases Humans In Situ Nick-End Labeling Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neoplastic Cells, Circulating - pathology Sezary Syndrome - blood Sezary Syndrome - drug therapy Sezary Syndrome - pathology Skin Neoplasms - blood Skin Neoplasms - drug therapy Staining and Labeling Sézary cells Tetrahydronaphthalenes - therapeutic use Tumor Cells, Cultured
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