Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid

Background The ability to differentiate adenomatous from nonadenomatous colonic polyps by using chromoendoscopy would obviate the need to remove hyperplastic lesions. The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology....

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Veröffentlicht in:Gastrointestinal endoscopy 2006-05, Vol.63 (6), p.824-828
Hauptverfasser: Dariusz, Apel, Ralf, Jakobs, Dieter, Schilling, Uwe, Weickert, Joachim, Teichmann, Bohrer, Manfred H., Ferdinand, Riemann Jürgen
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container_issue 6
container_start_page 824
container_title Gastrointestinal endoscopy
container_volume 63
creator Dariusz, Apel
Ralf, Jakobs
Dieter, Schilling
Uwe, Weickert
Joachim, Teichmann
Bohrer, Manfred H.
Ferdinand, Riemann Jürgen
description Background The ability to differentiate adenomatous from nonadenomatous colonic polyps by using chromoendoscopy would obviate the need to remove hyperplastic lesions. The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology. Methods In 158 patients, 273 polyps in the rectosigmoid and
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The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology. Methods In 158 patients, 273 polyps in the rectosigmoid and &lt;5 mm in size were estimated for their histology. The endoscopists, in two steps, predicted the histopathology of each lesion based on its surface characteristics: by using high-resolution colonoscope without any staining and after indigo carmine dye according to the Kudo classification. Results The resected polyps included 48 adenomatous and 225 nonadenomatous polyps. When comparing histologically confirmed hyperplastic to adenomatous polyps, the prediction of hyperplastic polyps based on endoscopic findings had a sensitivity of 93%, a specificity of 60%, and an overall accuracy of 81%. The corresponding sensitivity, specificity, and overall accuracy after indigo carmine dye were 94%, 64%, and 83%, respectively. Conclusions The results suggest that the chromoendoscopy only marginally improves the determination between hyperplastic and adenomatous polyps when using high-resolution colonoscopes. The overall accuracy rate increased after dyeing, from 81% to 83%. The renunciation of histopathologic analysis cannot yet be achieved by chromoendoscopy.</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1016/j.gie.2005.09.013</identifier><identifier>PMID: 16650546</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adenoma - pathology ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Colonic Neoplasms - pathology ; Colonic Polyps - pathology ; Colonoscopes ; Colonoscopy ; Color ; Coloring Agents - therapeutic use ; Digestive system. Abdomen ; Endoscopy ; Endoscopy, Gastrointestinal - methods ; Female ; Gastroenterology and Hepatology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hyperplasia - pathology ; Indigo Carmine - therapeutic use ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Sigmoid Neoplasms - pathology</subject><ispartof>Gastrointestinal endoscopy, 2006-05, Vol.63 (6), p.824-828</ispartof><rights>American Society for Gastrointestinal Endoscopy</rights><rights>2006 American Society for Gastrointestinal Endoscopy</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-c0e9f4436dd775dfb06d173bd56a1b28d75d4124df81e46e72716fc4e1d1e63e3</citedby><cites>FETCH-LOGICAL-c502t-c0e9f4436dd775dfb06d173bd56a1b28d75d4124df81e46e72716fc4e1d1e63e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016510705028117$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17771423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16650546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dariusz, Apel</creatorcontrib><creatorcontrib>Ralf, Jakobs</creatorcontrib><creatorcontrib>Dieter, Schilling</creatorcontrib><creatorcontrib>Uwe, Weickert</creatorcontrib><creatorcontrib>Joachim, Teichmann</creatorcontrib><creatorcontrib>Bohrer, Manfred H.</creatorcontrib><creatorcontrib>Ferdinand, Riemann Jürgen</creatorcontrib><title>Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background The ability to differentiate adenomatous from nonadenomatous colonic polyps by using chromoendoscopy would obviate the need to remove hyperplastic lesions. The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology. Methods In 158 patients, 273 polyps in the rectosigmoid and &lt;5 mm in size were estimated for their histology. The endoscopists, in two steps, predicted the histopathology of each lesion based on its surface characteristics: by using high-resolution colonoscope without any staining and after indigo carmine dye according to the Kudo classification. Results The resected polyps included 48 adenomatous and 225 nonadenomatous polyps. When comparing histologically confirmed hyperplastic to adenomatous polyps, the prediction of hyperplastic polyps based on endoscopic findings had a sensitivity of 93%, a specificity of 60%, and an overall accuracy of 81%. The corresponding sensitivity, specificity, and overall accuracy after indigo carmine dye were 94%, 64%, and 83%, respectively. Conclusions The results suggest that the chromoendoscopy only marginally improves the determination between hyperplastic and adenomatous polyps when using high-resolution colonoscopes. The overall accuracy rate increased after dyeing, from 81% to 83%. The renunciation of histopathologic analysis cannot yet be achieved by chromoendoscopy.</description><subject>Adenoma - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Polyps - pathology</subject><subject>Colonoscopes</subject><subject>Colonoscopy</subject><subject>Color</subject><subject>Coloring Agents - therapeutic use</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Endoscopy, Gastrointestinal - methods</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hyperplasia - pathology</subject><subject>Indigo Carmine - therapeutic use</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Sigmoid Neoplasms - pathology</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2LFDEQhoMo7rj6A7xIX9xbj6n-SKYRhGVRV1jwoJ5DT1LdU2N3Mqa6F8Zfb3pnYMHDngLJ874pHkqItyDXIEF92K97wnUhZb2WzVpC-UysQDY6V1o3z8VKJiivQeoL8Yp5L6XcFCW8FBegVC3rSq3E32tr59jaYxa6bEf9Lo_IYZgnCj6zuxjGgN4FtuFwzMhnh4iO7MPrQ4CnMISebNaRd-R7XiBHI_lUcY_ZgJxYXuBph1lEOwWmfgzkXosXXTswvjmfl-LXl88_b27zu-9fv91c3-W2lsWUW4lNV1Wlck7r2nVbqRzocutq1cK22Lh0WUFRuW4DWCnUhQbV2QrBAaoSy0txdeo9xPBnRp7MSGxxGFqPYWajdFPUZVUmEE6gjYE5YmcOkcY2Hg1Iswg3e5OEm0W4kY1JwlPm3bl83o7oHhNnwwl4fwZatu3QxdZb4kdOaw1VsRR9PHGYVNwTRsOW0Nuke5FmXKAnx_j0X9oO5Cl9-BuPyPswR58cGzBcGGl-LJuxLIZMijeQdP4D-BO1bQ</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Dariusz, Apel</creator><creator>Ralf, Jakobs</creator><creator>Dieter, Schilling</creator><creator>Uwe, Weickert</creator><creator>Joachim, Teichmann</creator><creator>Bohrer, Manfred H.</creator><creator>Ferdinand, Riemann Jürgen</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid</title><author>Dariusz, Apel ; Ralf, Jakobs ; Dieter, Schilling ; Uwe, Weickert ; Joachim, Teichmann ; Bohrer, Manfred H. ; Ferdinand, Riemann Jürgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-c0e9f4436dd775dfb06d173bd56a1b28d75d4124df81e46e72716fc4e1d1e63e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenoma - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Polyps - pathology</topic><topic>Colonoscopes</topic><topic>Colonoscopy</topic><topic>Color</topic><topic>Coloring Agents - therapeutic use</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Endoscopy, Gastrointestinal - methods</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hyperplasia - pathology</topic><topic>Indigo Carmine - therapeutic use</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Sigmoid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dariusz, Apel</creatorcontrib><creatorcontrib>Ralf, Jakobs</creatorcontrib><creatorcontrib>Dieter, Schilling</creatorcontrib><creatorcontrib>Uwe, Weickert</creatorcontrib><creatorcontrib>Joachim, Teichmann</creatorcontrib><creatorcontrib>Bohrer, Manfred H.</creatorcontrib><creatorcontrib>Ferdinand, Riemann Jürgen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dariusz, Apel</au><au>Ralf, Jakobs</au><au>Dieter, Schilling</au><au>Uwe, Weickert</au><au>Joachim, Teichmann</au><au>Bohrer, Manfred H.</au><au>Ferdinand, Riemann Jürgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>63</volume><issue>6</issue><spage>824</spage><epage>828</epage><pages>824-828</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background The ability to differentiate adenomatous from nonadenomatous colonic polyps by using chromoendoscopy would obviate the need to remove hyperplastic lesions. The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology. Methods In 158 patients, 273 polyps in the rectosigmoid and &lt;5 mm in size were estimated for their histology. The endoscopists, in two steps, predicted the histopathology of each lesion based on its surface characteristics: by using high-resolution colonoscope without any staining and after indigo carmine dye according to the Kudo classification. Results The resected polyps included 48 adenomatous and 225 nonadenomatous polyps. When comparing histologically confirmed hyperplastic to adenomatous polyps, the prediction of hyperplastic polyps based on endoscopic findings had a sensitivity of 93%, a specificity of 60%, and an overall accuracy of 81%. The corresponding sensitivity, specificity, and overall accuracy after indigo carmine dye were 94%, 64%, and 83%, respectively. Conclusions The results suggest that the chromoendoscopy only marginally improves the determination between hyperplastic and adenomatous polyps when using high-resolution colonoscopes. The overall accuracy rate increased after dyeing, from 81% to 83%. The renunciation of histopathologic analysis cannot yet be achieved by chromoendoscopy.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>16650546</pmid><doi>10.1016/j.gie.2005.09.013</doi><tpages>5</tpages></addata></record>
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subjects Adenoma - pathology
Aged
Aged, 80 and over
Biological and medical sciences
Colonic Neoplasms - pathology
Colonic Polyps - pathology
Colonoscopes
Colonoscopy
Color
Coloring Agents - therapeutic use
Digestive system. Abdomen
Endoscopy
Endoscopy, Gastrointestinal - methods
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hyperplasia - pathology
Indigo Carmine - therapeutic use
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Sigmoid Neoplasms - pathology
title Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid
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