Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

Regioselective alkylation of 2-alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-one (1) and 2-alkyl-3H-cycloheptimidazol-4-one (2) was investigated. 3-[2′-(1-tert-Butyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-2-propyl-5,6,7,8-tetrahydro-1H-cycloheptimidazol-4-one (6) was preferentially obtained under t...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2006, Vol.54(5), pp.706-710
Hauptverfasser:	Sonegawa, Motoharu, Yokota, Masayuki, Tomiyama, Hiroshi, Tomiyama, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	4-acylimidazole Alkylation angiotensin receptor antagonist Catalysis Cycloheptanes - chemistry cycloheptimidazol-4-one Imidazoles - chemistry Magnetic Resonance Spectroscopy phase transfer catalyst Pratosartan regioselective alkylation Solutions Solvents Spectrophotometry, Infrared
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