Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections

Mice lacking a functional cyclooxygenase-2 (COX-2) gene develop abnormal kidneys that contain hypoplastic glomeruli and reduced proximal tubular mass, and they often die of renal failure. A comparison of kidney-specific gene expression between wild-type and COX-2-deficient mice by cDNA microarrays r...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2005-07, Vol.289 (1), p.F49-F60
Hauptverfasser:	Dou, Wenkai, Thompson-Jaeger, Sandra, Laulederkind, Stanley J F, Becker, John W, Montgomery, Julia, Ruiz-Bustos, Eduardo, Hasty, David L, Ballou, Leslie R, Eastman, P Scott, Srichai, Betsy, Breyer, Matthew D, Raghow, Rajendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 2 Escherichia coli Infections - genetics Escherichia coli Infections - physiopathology Female Gene Expression Profiling Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Genetic Predisposition to Disease Kidney - metabolism Kidney - pathology Male Mice Mice, Knockout Mucoproteins - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - physiology Urinary Tract Infections - genetics Urinary Tract Infections - physiopathology Uromodulin
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