Epigenetic Profiling of Cutaneous T-Cell Lymphoma: Promoter Hypermethylation of Multiple Tumor Suppressor Genes Including BCL7a, PTPRG, and p73

To analyze the occurrence of promoter hypermethylation in primary cutaneous T-cell lymphoma (CTCL) on a genome-wide scale, focusing on epigenetic alterations with pathogenetic significance. DNA isolated from biopsy specimens of 28 patients with CTCL, including aggressive CTCL entities (transformed m...

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Veröffentlicht in:	Journal of clinical oncology 2005-06, Vol.23 (17), p.3886-3896
Hauptverfasser:	VAN DOOM, Remco, ZOUTMAN, Willem H, HUANG, Tim H, TENSEN, Cornelis P, DIJKMAN, Remco, DE MENEZES, Renee X, COMMANDEUR, Suzan, MULDER, Aat A, VAN DER VELDEN, Pieter A, VERMEER, Maarten H, WILLEMZE, Rein, YAN, Pearily S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence Biological and medical sciences CpG Islands DNA Methylation DNA, Neoplasm - genetics DNA-Binding Proteins - genetics Epigenesis, Genetic Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Silencing Genes, Tumor Suppressor - physiology Genome, Human Hematologic and hematopoietic diseases Humans Ki-1 Antigen - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, T-Cell, Cutaneous - genetics Male Medical sciences Microarray Analysis Microfilament Proteins - genetics Middle Aged Molecular Sequence Data Nerve Tissue Proteins - genetics Nuclear Proteins - genetics Oncogene Proteins - genetics Promoter Regions, Genetic Protein Tyrosine Phosphatases - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 5 Skin Neoplasms - genetics Thrombospondins - genetics Tumor Protein p73 Tumor Suppressor Proteins Tumors
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