Interferon-γ and atherosclerosis : Pro- or anti-atherogenic?
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-...
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| Veröffentlicht in: | Cardiovascular research 2005-07, Vol.67 (1), p.11-20 |
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| container_title | Cardiovascular research |
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| creator | HARVEY, Elizabeth J RAMJI, Dipak P |
| description | Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling. |
| doi_str_mv | 10.1016/j.cardiores.2005.04.019 |
| format | Article |
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The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling.</description><subject>Animals</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - immunology</subject><subject>Atherosclerosis - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Chemokines - immunology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Humans</subject><subject>Interferon-gamma - genetics</subject><subject>Interferon-gamma - physiology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lipoproteins - metabolism</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Muscle, Smooth, Vascular - immunology</subject><subject>Signal Transduction - physiology</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtOwzAQQC0EoqVwBcgGdg5jx18khFDFp1IlWMDachwHUqVJsdMF5-IenAlXrehmRqN589FD6IJAToCI60XubKiaPviYUwCeA8uB6AM0JpJzXFDGD9EYABQWhShG6CTGRSo5l-wYjQjXIBWFMbqddYMPtQ99h39_MttVmR0-Uxldu4lNzG6y19DjrA-pOzR42_7wXePuTtFRbdvoz3Z5gt4fH96mz3j-8jSb3s-xK4BrTDUvKxAV9VQoWUuqrSJClc57UVomdQmVSgylUALjqtKSOe1ICaVOD-tigq62e1eh_1r7OJhlE51vW9v5fh2NkJpSwUQC5RZ06fcYfG1WoVna8G0ImI05szD_5szGnAFmkrk0eb47sS6XvtrP7VQl4HIH2OhsWwfbuSbuOaEUY8n1Hwb6eUg</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>HARVEY, Elizabeth J</creator><creator>RAMJI, Dipak P</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Interferon-γ and atherosclerosis : Pro- or anti-atherogenic?</title><author>HARVEY, Elizabeth J ; RAMJI, Dipak P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3059-295bd06d2e2687f729a8168bcee6ba479b0d895b220b0458d974c9c1b0b957493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - immunology</topic><topic>Atherosclerosis - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Chemokines - immunology</topic><topic>Endothelium, Vascular - immunology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Humans</topic><topic>Interferon-gamma - genetics</topic><topic>Interferon-gamma - physiology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lipoproteins - metabolism</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Muscle, Smooth, Vascular - immunology</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARVEY, Elizabeth J</creatorcontrib><creatorcontrib>RAMJI, Dipak P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARVEY, Elizabeth J</au><au>RAMJI, Dipak P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon-γ and atherosclerosis : Pro- or anti-atherogenic?</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>67</volume><issue>1</issue><spage>11</spage><epage>20</epage><pages>11-20</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15907820</pmid><doi>10.1016/j.cardiores.2005.04.019</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cardiovascular research, 2005-07, Vol.67 (1), p.11-20 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Atherosclerosis (general aspects, experimental research) Atherosclerosis - immunology Atherosclerosis - metabolism Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Adhesion Molecules - metabolism Chemokines - immunology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Humans Interferon-gamma - genetics Interferon-gamma - physiology Killer Cells, Natural - immunology Lipoproteins - metabolism Macrophages - immunology Medical sciences Mice Mice, Knockout Muscle, Smooth, Vascular - immunology Signal Transduction - physiology |
| title | Interferon-γ and atherosclerosis : Pro- or anti-atherogenic? |
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