Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne’s Muscular Dystrophy
Doppler tissue velocities (DTV) are abnormal in a variety of cardiac conditions when standard measures of ventricular function are normal. Detection of left ventricular dysfunction in Duchenne’s muscular dystrophy (DMD) has relied on 2-dimensional imaging yet often these images are suboptimal. This...
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| Veröffentlicht in: | Journal of the American Society of Echocardiography 2005-06, Vol.18 (6), p.666-673 |
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| creator | Bahler, Robert C. Mohyuddin, Tayyab Finkelhor, Robert S. Jacobs, Irwin B. |
| description | Doppler tissue velocities (DTV) are abnormal in a variety of cardiac conditions when standard measures of ventricular function are normal. Detection of left ventricular dysfunction in Duchenne’s muscular dystrophy (DMD) has relied on 2-dimensional imaging yet often these images are suboptimal. This study was undertaken to determine if DTV and the myocardial performance index (MPI) could provide additional diagnostic information in DMD. We determined in 31 patients and 13 age-matched control subjects the prevalence of both abnormal DTV of the mitral annulus and abnormal MPI. Mean values for early diastolic DTV were significantly lower for patients compared with control subjects (
P < .001) and were abnormally low in 86% of patients. The MPI was abnormal in 79% of patients. All but one patient with DMD had either abnormal DTV or abnormal MPI yet 19% had normal fractional shortening. DTV and MPI are important additions to the echocardiographic evaluation of patients with DMD. |
| doi_str_mv | 10.1016/j.echo.2004.10.003 |
| format | Article |
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P < .001) and were abnormally low in 86% of patients. The MPI was abnormal in 79% of patients. All but one patient with DMD had either abnormal DTV or abnormal MPI yet 19% had normal fractional shortening. DTV and MPI are important additions to the echocardiographic evaluation of patients with DMD.</description><identifier>ISSN: 0894-7317</identifier><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2004.10.003</identifier><identifier>PMID: 15947771</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Child ; Comorbidity ; Echocardiography, Doppler - statistics & numerical data ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Male ; Muscular Dystrophy, Duchenne - diagnostic imaging ; Muscular Dystrophy, Duchenne - epidemiology ; Ohio - epidemiology ; Prevalence ; Risk Assessment - methods ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - epidemiology</subject><ispartof>Journal of the American Society of Echocardiography, 2005-06, Vol.18 (6), p.666-673</ispartof><rights>2005 American Society of Echocardiography</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-ffd5bd3fcda5c776b99b8b606cd3255270638409e9eb658f6ec96145f06d0fa23</citedby><cites>FETCH-LOGICAL-c354t-ffd5bd3fcda5c776b99b8b606cd3255270638409e9eb658f6ec96145f06d0fa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0894731704009253$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15947771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahler, Robert C.</creatorcontrib><creatorcontrib>Mohyuddin, Tayyab</creatorcontrib><creatorcontrib>Finkelhor, Robert S.</creatorcontrib><creatorcontrib>Jacobs, Irwin B.</creatorcontrib><title>Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne’s Muscular Dystrophy</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description>Doppler tissue velocities (DTV) are abnormal in a variety of cardiac conditions when standard measures of ventricular function are normal. Detection of left ventricular dysfunction in Duchenne’s muscular dystrophy (DMD) has relied on 2-dimensional imaging yet often these images are suboptimal. This study was undertaken to determine if DTV and the myocardial performance index (MPI) could provide additional diagnostic information in DMD. We determined in 31 patients and 13 age-matched control subjects the prevalence of both abnormal DTV of the mitral annulus and abnormal MPI. Mean values for early diastolic DTV were significantly lower for patients compared with control subjects (
P < .001) and were abnormally low in 86% of patients. The MPI was abnormal in 79% of patients. All but one patient with DMD had either abnormal DTV or abnormal MPI yet 19% had normal fractional shortening. DTV and MPI are important additions to the echocardiographic evaluation of patients with DMD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Echocardiography, Doppler - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Male</subject><subject>Muscular Dystrophy, Duchenne - diagnostic imaging</subject><subject>Muscular Dystrophy, Duchenne - epidemiology</subject><subject>Ohio - epidemiology</subject><subject>Prevalence</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><issn>0894-7317</issn><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb-O1DAQhy0E4paDF6BAruiyOH9sJxLNaZeDk_bEFQet5djjW68SO9gOsB2vQc2b8SQ47Ep0VJbG33yjmR9CL0uyLknJ3hzWoPZ-XRHS5MKakPoRWpWk4wXjHX2MVqTtmoLXJb9Az2I8EEJoS8hTdFHSruGclyv0a-NdCrafk_UOe4O3fpoGCPjexjgDvhnlg3UPWDqNb49eyaCtHPAdBOPDKJ3KiNPwHSePr2KEGEdwaRHtwCT8GRa7mgcZ8PXs1N8p1uE7mWz-ivibTXu8ndUenIPfP35GfDvHE789xhT8tD8-R0-MHCK8OL-X6NP1u_vNh2L38f3N5mpXqJo2qTBG017XRmlJFees77q-7RlhStcVpRUnrG4b0kEHPaOtYaA6VjbUEKaJkVV9iV6fvFPwX2aISYw2KhgG6cDPUeSrVlXTthmsTqAKPsYARkzBjjIcRUnEEo04iCUasUSz1HI0uenV2T73I-h_LecsMvD2BEDe8auFIKLKR1KgbQCVhPb2f_4_p3mkqg</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Bahler, Robert C.</creator><creator>Mohyuddin, Tayyab</creator><creator>Finkelhor, Robert S.</creator><creator>Jacobs, Irwin B.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne’s Muscular Dystrophy</title><author>Bahler, Robert C. ; Mohyuddin, Tayyab ; Finkelhor, Robert S. ; Jacobs, Irwin B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-ffd5bd3fcda5c776b99b8b606cd3255270638409e9eb658f6ec96145f06d0fa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Echocardiography, Doppler - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Male</topic><topic>Muscular Dystrophy, Duchenne - diagnostic imaging</topic><topic>Muscular Dystrophy, Duchenne - epidemiology</topic><topic>Ohio - epidemiology</topic><topic>Prevalence</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahler, Robert C.</creatorcontrib><creatorcontrib>Mohyuddin, Tayyab</creatorcontrib><creatorcontrib>Finkelhor, Robert S.</creatorcontrib><creatorcontrib>Jacobs, Irwin B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahler, Robert C.</au><au>Mohyuddin, Tayyab</au><au>Finkelhor, Robert S.</au><au>Jacobs, Irwin B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne’s Muscular Dystrophy</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>18</volume><issue>6</issue><spage>666</spage><epage>673</epage><pages>666-673</pages><issn>0894-7317</issn><eissn>1097-6795</eissn><abstract>Doppler tissue velocities (DTV) are abnormal in a variety of cardiac conditions when standard measures of ventricular function are normal. 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P < .001) and were abnormally low in 86% of patients. The MPI was abnormal in 79% of patients. All but one patient with DMD had either abnormal DTV or abnormal MPI yet 19% had normal fractional shortening. DTV and MPI are important additions to the echocardiographic evaluation of patients with DMD.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>15947771</pmid><doi>10.1016/j.echo.2004.10.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of the American Society of Echocardiography, 2005-06, Vol.18 (6), p.666-673 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Child Comorbidity Echocardiography, Doppler - statistics & numerical data Female Humans Image Interpretation, Computer-Assisted - methods Male Muscular Dystrophy, Duchenne - diagnostic imaging Muscular Dystrophy, Duchenne - epidemiology Ohio - epidemiology Prevalence Risk Assessment - methods Risk Factors Sensitivity and Specificity Severity of Illness Index Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - epidemiology |
| title | Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne’s Muscular Dystrophy |
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