Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

The substrate specificities of papain-like cysteine proteases (clan CA, family C1) papain, bromelain, and human cathepsins L, V, K, S, F, B, and five proteases of parasitic origin were studied using a completely diversified positional scanning synthetic combinatorial library. A bifunctional coumarin...

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Veröffentlicht in:	The Journal of biological chemistry 2006-05, Vol.281 (18), p.12824-12832
Hauptverfasser:	Choe, Youngchool, Leonetti, Francesco, Greenbaum, Doron C., Lecaille, Fabien, Bogyo, Matthew, Brömme, Dieter, Ellman, Jonathan A., Craik, Charles S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Cathepsin K Cathepsins - chemistry Coumarins - chemistry Cysteine - chemistry Humans Ketones - chemistry Kinetics Models, Chemical Peptides - chemistry Phylogeny Substrate Specificity
Online-Zugang:	Volltext
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