Menin links estrogen receptor activation to histone H3K4 trimethylation

The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-05, Vol.66 (9), p.4929-4935
Hauptverfasser:	DREIJERINK, Koen M. A, MULDER, Klaas W, WINKLER, G. Sebastiaan, HÖPPENER, Jo W. M, LIPS, Cornelis J. M, MARC TIMMERS, H. Th
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cercopithecus aethiops COS Cells DNA Methylation Estrogen Receptor alpha - metabolism Gene Expression Histones - genetics Histones - metabolism Humans Medical sciences Mutation Pharmacology. Drug treatments Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Transcriptional Activation - physiology Trefoil Factor-1 Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Tumors
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