Effects of Antifungal Drugs on Proliferation Signals in Candida albicans
The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured. Ciclopirox olamine and siccanin were more effective under aerobic than under anaerobic conditions. Terbinafine, neticonazole and amphotericin B showed the same antifungal activi...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2006, Vol.29(5), pp.919-922 |
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| container_title | Biological & Pharmaceutical Bulletin |
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| creator | Matsuki, Mitsuo Kanatsu, Hatsuki Watanabe, Toshihiko Ogasawara, Ayako Mikami, Takeshi Matsumoto, Tatsuji |
| description | The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured. Ciclopirox olamine and siccanin were more effective under aerobic than under anaerobic conditions. Terbinafine, neticonazole and amphotericin B showed the same antifungal activity under both aerobic and anaerobic conditions. None of these antifungal activities were affected by the pH conditions. Terbinafine inhibited the elongation of hyphae, while neticonazole and amphotericin B induced proliferation of the yeast form. The expression of RAS1, EFG1 and CPH1 mRNAs was inhibited by these drugs. These results suggested that the inhibition of hyphal formation might be caused by disruption of the RAS1-signal pathway. |
| doi_str_mv | 10.1248/bpb.29.919 |
| format | Article |
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Ciclopirox olamine and siccanin were more effective under aerobic than under anaerobic conditions. Terbinafine, neticonazole and amphotericin B showed the same antifungal activity under both aerobic and anaerobic conditions. None of these antifungal activities were affected by the pH conditions. Terbinafine inhibited the elongation of hyphae, while neticonazole and amphotericin B induced proliferation of the yeast form. The expression of RAS1, EFG1 and CPH1 mRNAs was inhibited by these drugs. These results suggested that the inhibition of hyphal formation might be caused by disruption of the RAS1-signal pathway.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.29.919</identifier><identifier>PMID: 16651719</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Aerobiosis ; amphotericin B ; Anaerobiosis ; Antifungal Agents - pharmacology ; Candida albicans ; Candida albicans - drug effects ; Candida albicans - growth & development ; Cell Proliferation - drug effects ; ciclopirox olamine ; Fungal Proteins - biosynthesis ; Hydrogen-Ion Concentration ; Hyphae - drug effects ; Indicators and Reagents ; neticonazole ; RNA, Fungal - biosynthesis ; RNA, Messenger - biosynthesis ; siccanin ; Signal Transduction - drug effects ; terbinafine</subject><ispartof>Biological and Pharmaceutical Bulletin, 2006, Vol.29(5), pp.919-922</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c715t-6285fd046cdf6f01c4c8cb06b9f5c979f746eba369de74f27e5df6de0c9d17e83</citedby><cites>FETCH-LOGICAL-c715t-6285fd046cdf6f01c4c8cb06b9f5c979f746eba369de74f27e5df6de0c9d17e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16651719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuki, Mitsuo</creatorcontrib><creatorcontrib>Kanatsu, Hatsuki</creatorcontrib><creatorcontrib>Watanabe, Toshihiko</creatorcontrib><creatorcontrib>Ogasawara, Ayako</creatorcontrib><creatorcontrib>Mikami, Takeshi</creatorcontrib><creatorcontrib>Matsumoto, Tatsuji</creatorcontrib><creatorcontrib>Department of Microbiology</creatorcontrib><creatorcontrib>Tohoku Pharmaceutical University</creatorcontrib><title>Effects of Antifungal Drugs on Proliferation Signals in Candida albicans</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured. Ciclopirox olamine and siccanin were more effective under aerobic than under anaerobic conditions. Terbinafine, neticonazole and amphotericin B showed the same antifungal activity under both aerobic and anaerobic conditions. None of these antifungal activities were affected by the pH conditions. Terbinafine inhibited the elongation of hyphae, while neticonazole and amphotericin B induced proliferation of the yeast form. The expression of RAS1, EFG1 and CPH1 mRNAs was inhibited by these drugs. These results suggested that the inhibition of hyphal formation might be caused by disruption of the RAS1-signal pathway.</description><subject>Aerobiosis</subject><subject>amphotericin B</subject><subject>Anaerobiosis</subject><subject>Antifungal Agents - pharmacology</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - growth & development</subject><subject>Cell Proliferation - drug effects</subject><subject>ciclopirox olamine</subject><subject>Fungal Proteins - biosynthesis</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hyphae - drug effects</subject><subject>Indicators and Reagents</subject><subject>neticonazole</subject><subject>RNA, Fungal - biosynthesis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>siccanin</subject><subject>Signal Transduction - drug effects</subject><subject>terbinafine</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNY7Fp98QPIgOCDMNvczOTfk5S1tUKhBfU5ZDLJmiWbrMnMQ7-9WWZrwRdfbkjOL-cm9yD0DvAaSC8uh8OwJnItQb5AK-h63lIC9CVaYQmiZUDFOXpdyg5jzDHpXqFzYIwCB7lCt9fOWTOVJrnmKk7ezXGrQ_Mlz9t6FpuHnIJ3NuvJ1913v406lMbHZqPj6Efd6DB4o2N5g85clezb03qBft5c_9jctnf3X79tru5aw4FOLSOCuhH3zIyOOQymN8IMmA3SUSO5dLxndtAdk6PlvSPc0gqOFhs5Areiu0AfF99DTr9nWya198XYEHS0aS6KcUmAEfZfEGSHBQdewQ__gLs05-M_FfS97KjgjFbq00KZnErJ1qlD9nudHxVgdYxB1RgUkarGUOH3J8t52NvxGT3NvQI3C1DVOr6QYvDRPjc2hQ8-haQIxkxhTCSmCgOoGqmshRAqaoFq9Hkx2pVJb-3fTjpP3gT79Ci6lOPlJ8X80lnZ2P0Bj-SvHw</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Matsuki, Mitsuo</creator><creator>Kanatsu, Hatsuki</creator><creator>Watanabe, Toshihiko</creator><creator>Ogasawara, Ayako</creator><creator>Mikami, Takeshi</creator><creator>Matsumoto, Tatsuji</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7T7</scope><scope>C1K</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Effects of Antifungal Drugs on Proliferation Signals in Candida albicans</title><author>Matsuki, Mitsuo ; Kanatsu, Hatsuki ; Watanabe, Toshihiko ; Ogasawara, Ayako ; Mikami, Takeshi ; Matsumoto, Tatsuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c715t-6285fd046cdf6f01c4c8cb06b9f5c979f746eba369de74f27e5df6de0c9d17e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aerobiosis</topic><topic>amphotericin B</topic><topic>Anaerobiosis</topic><topic>Antifungal Agents - pharmacology</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - growth & development</topic><topic>Cell Proliferation - drug effects</topic><topic>ciclopirox olamine</topic><topic>Fungal Proteins - biosynthesis</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hyphae - drug effects</topic><topic>Indicators and Reagents</topic><topic>neticonazole</topic><topic>RNA, Fungal - biosynthesis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>siccanin</topic><topic>Signal Transduction - drug effects</topic><topic>terbinafine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuki, Mitsuo</creatorcontrib><creatorcontrib>Kanatsu, Hatsuki</creatorcontrib><creatorcontrib>Watanabe, Toshihiko</creatorcontrib><creatorcontrib>Ogasawara, Ayako</creatorcontrib><creatorcontrib>Mikami, Takeshi</creatorcontrib><creatorcontrib>Matsumoto, Tatsuji</creatorcontrib><creatorcontrib>Department of Microbiology</creatorcontrib><creatorcontrib>Tohoku Pharmaceutical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuki, Mitsuo</au><au>Kanatsu, Hatsuki</au><au>Watanabe, Toshihiko</au><au>Ogasawara, Ayako</au><au>Mikami, Takeshi</au><au>Matsumoto, Tatsuji</au><aucorp>Department of Microbiology</aucorp><aucorp>Tohoku Pharmaceutical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Antifungal Drugs on Proliferation Signals in Candida albicans</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>29</volume><issue>5</issue><spage>919</spage><epage>922</epage><pages>919-922</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The sensitivity of Candida albicans to antifungal drugs when cultured under aerobic and anaerobic conditions was measured. 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| subjects | Aerobiosis amphotericin B Anaerobiosis Antifungal Agents - pharmacology Candida albicans Candida albicans - drug effects Candida albicans - growth & development Cell Proliferation - drug effects ciclopirox olamine Fungal Proteins - biosynthesis Hydrogen-Ion Concentration Hyphae - drug effects Indicators and Reagents neticonazole RNA, Fungal - biosynthesis RNA, Messenger - biosynthesis siccanin Signal Transduction - drug effects terbinafine |
| title | Effects of Antifungal Drugs on Proliferation Signals in Candida albicans |
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