Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum
The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants. The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations. Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendru...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmacy & pharmaceutical sciences 2005-03, Vol.8 (1), p.63-68 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 68 |
|---|---|
| container_issue | 1 |
| container_start_page | 63 |
| container_title | Journal of pharmacy & pharmaceutical sciences |
| container_volume | 8 |
| creator | Emendörfer, Fernanda Emendörfer, Fabiane Bellato, Fernanda Noldin, Vânia F Niero, Rivaldo Cechinel-Filho, Valdir Cardozo, Alcibia Maia |
| description | The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants.
The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations.
Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner.
The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67921423</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67921423</sourcerecordid><originalsourceid>FETCH-LOGICAL-p209t-d945383b1063190a86b381079bb631d149adf55db79e3b395d82136a7196b7bf3</originalsourceid><addsrcrecordid>eNo1kEtLxDAcxIMg7rr6FSQnb4U82rQ56rI-YMGLnss_TbpG0qTmIeqnt-DuaWD4MczMGVrTumMV7ZhYocuUPghhnElygVa0kbVopFyjuPsCVyDb4HEYcX43OBoH3-AzhuFkpzAZfB_h1zoLHk9G28F6cHh2C5iw9dim4CAbjQ_FegPVbA_YOlMmDF7jCBnrErTxZbpC5yO4ZK6PukFvD7vX7VO1f3l83t7tq5kRmSst64Z3XFEiOJUEOqF4R0krlVoMTWsJemwarVppuOKy0R2jXEBLpVCtGvkG3f7nzjF8FpNyP9k0GLdUNqGkXrSS0ZrxBbw5gkUt0_o52gniT396if8B9tNjTw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67921423</pqid></control><display><type>article</type><title>Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Emendörfer, Fernanda ; Emendörfer, Fabiane ; Bellato, Fernanda ; Noldin, Vânia F ; Niero, Rivaldo ; Cechinel-Filho, Valdir ; Cardozo, Alcibia Maia</creator><creatorcontrib>Emendörfer, Fernanda ; Emendörfer, Fabiane ; Bellato, Fernanda ; Noldin, Vânia F ; Niero, Rivaldo ; Cechinel-Filho, Valdir ; Cardozo, Alcibia Maia</creatorcontrib><description>The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants.
The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations.
Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner.
The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders.</description><identifier>EISSN: 1482-1826</identifier><identifier>PMID: 15946599</identifier><language>eng</language><publisher>Canada</publisher><subject>Animals ; Brazil ; Calophyllum ; Cynara scolymus ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical - methods ; Duodenum - drug effects ; Duodenum - physiology ; Female ; Guinea Pigs ; Ileum - drug effects ; Ileum - physiology ; In Vitro Techniques ; Male ; Muscle Relaxation - drug effects ; Muscle Relaxation - physiology ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Plant Components, Aerial ; Plant Extracts - pharmacology ; Plant Roots ; Plants, Medicinal ; Rats ; Rats, Wistar</subject><ispartof>Journal of pharmacy & pharmaceutical sciences, 2005-03, Vol.8 (1), p.63-68</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15946599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emendörfer, Fernanda</creatorcontrib><creatorcontrib>Emendörfer, Fabiane</creatorcontrib><creatorcontrib>Bellato, Fernanda</creatorcontrib><creatorcontrib>Noldin, Vânia F</creatorcontrib><creatorcontrib>Niero, Rivaldo</creatorcontrib><creatorcontrib>Cechinel-Filho, Valdir</creatorcontrib><creatorcontrib>Cardozo, Alcibia Maia</creatorcontrib><title>Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum</title><title>Journal of pharmacy & pharmaceutical sciences</title><addtitle>J Pharm Pharm Sci</addtitle><description>The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants.
The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations.
Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner.
The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders.</description><subject>Animals</subject><subject>Brazil</subject><subject>Calophyllum</subject><subject>Cynara scolymus</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - physiology</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>Ileum - physiology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle Relaxation - physiology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1482-1826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAcxIMg7rr6FSQnb4U82rQ56rI-YMGLnss_TbpG0qTmIeqnt-DuaWD4MczMGVrTumMV7ZhYocuUPghhnElygVa0kbVopFyjuPsCVyDb4HEYcX43OBoH3-AzhuFkpzAZfB_h1zoLHk9G28F6cHh2C5iw9dim4CAbjQ_FegPVbA_YOlMmDF7jCBnrErTxZbpC5yO4ZK6PukFvD7vX7VO1f3l83t7tq5kRmSst64Z3XFEiOJUEOqF4R0krlVoMTWsJemwarVppuOKy0R2jXEBLpVCtGvkG3f7nzjF8FpNyP9k0GLdUNqGkXrSS0ZrxBbw5gkUt0_o52gniT396if8B9tNjTw</recordid><startdate>20050318</startdate><enddate>20050318</enddate><creator>Emendörfer, Fernanda</creator><creator>Emendörfer, Fabiane</creator><creator>Bellato, Fernanda</creator><creator>Noldin, Vânia F</creator><creator>Niero, Rivaldo</creator><creator>Cechinel-Filho, Valdir</creator><creator>Cardozo, Alcibia Maia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050318</creationdate><title>Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum</title><author>Emendörfer, Fernanda ; Emendörfer, Fabiane ; Bellato, Fernanda ; Noldin, Vânia F ; Niero, Rivaldo ; Cechinel-Filho, Valdir ; Cardozo, Alcibia Maia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-d945383b1063190a86b381079bb631d149adf55db79e3b395d82136a7196b7bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Brazil</topic><topic>Calophyllum</topic><topic>Cynara scolymus</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Duodenum - drug effects</topic><topic>Duodenum - physiology</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>Ileum - physiology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle Relaxation - physiology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Plant Components, Aerial</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emendörfer, Fernanda</creatorcontrib><creatorcontrib>Emendörfer, Fabiane</creatorcontrib><creatorcontrib>Bellato, Fernanda</creatorcontrib><creatorcontrib>Noldin, Vânia F</creatorcontrib><creatorcontrib>Niero, Rivaldo</creatorcontrib><creatorcontrib>Cechinel-Filho, Valdir</creatorcontrib><creatorcontrib>Cardozo, Alcibia Maia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy & pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emendörfer, Fernanda</au><au>Emendörfer, Fabiane</au><au>Bellato, Fernanda</au><au>Noldin, Vânia F</au><au>Niero, Rivaldo</au><au>Cechinel-Filho, Valdir</au><au>Cardozo, Alcibia Maia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum</atitle><jtitle>Journal of pharmacy & pharmaceutical sciences</jtitle><addtitle>J Pharm Pharm Sci</addtitle><date>2005-03-18</date><risdate>2005</risdate><volume>8</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><eissn>1482-1826</eissn><abstract>The present study aimed to evaluate the possible antispasmodic activity in vitro of methanolic extracts (ME) of six Brazilian medicinal plants.
The extracts were evaluated on isolated guinea-pig ileum and rat duodenum preparations.
Rubus imperialis, Maytenus robusta, Ipomoea pes caprae and Epidendrum mosenii did not inhibit the contractile response elicited by acetylcholine on guinea-pig ileum. On the other hand, ME from Calophyllum brasiliense and Cynara scolymus exhibited significant inhibitory activity for the contractile response elicited by acetylcholine on guinea-pig ileum and on rat duodenum in a noncompetitive and concentration-dependent manner.
The current study suggests that, of the six medicinal plants evaluated, only the ME of Calophyllum brasiliense and Cynara scolymus show probable antispasmodic activity, confirming and justifying their use in folk medicine for the treatment of intestinal disorders.</abstract><cop>Canada</cop><pmid>15946599</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1482-1826 |
| ispartof | Journal of pharmacy & pharmaceutical sciences, 2005-03, Vol.8 (1), p.63-68 |
| issn | 1482-1826 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67921423 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Brazil Calophyllum Cynara scolymus Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Duodenum - drug effects Duodenum - physiology Female Guinea Pigs Ileum - drug effects Ileum - physiology In Vitro Techniques Male Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology Plant Components, Aerial Plant Extracts - pharmacology Plant Roots Plants, Medicinal Rats Rats, Wistar |
| title | Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T05%3A28%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20relaxant%20action%20of%20some%20Brazilian%20medicinal%20plants%20in%20isolated%20guinea-pig%20ileum%20and%20rat%20duodenum&rft.jtitle=Journal%20of%20pharmacy%20&%20pharmaceutical%20sciences&rft.au=Emend%C3%B6rfer,%20Fernanda&rft.date=2005-03-18&rft.volume=8&rft.issue=1&rft.spage=63&rft.epage=68&rft.pages=63-68&rft.eissn=1482-1826&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E67921423%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67921423&rft_id=info:pmid/15946599&rfr_iscdi=true |