BTB Domain-containing Speckle-type POZ Protein (SPOP) Serves as an Adaptor of Daxx for Ubiquitination by Cul3-based Ubiquitin Ligase

Daxx is a multifunctional protein that regulates a variety of cellular processes, including transcription, cell cycle, and apoptosis. SPOP is a BTB (Bric-a-brac/Tramtrack/Broad complex) protein that constitutes Cul3-based ubiquitin ligases. Here we show that SPOP serves as an adaptor of Daxx for the...

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Veröffentlicht in:	The Journal of biological chemistry 2006-05, Vol.281 (18), p.12664-12672
Hauptverfasser:	Kwon, Jeong Eun, La, Muhnho, Oh, Kyu Hee, Oh, Young Mi, Kim, Gi Ryang, Seol, Jae Hong, Baek, Sung Hee, Chiba, Tomoki, Tanaka, Keiji, Bang, Ok Sun, Joe, Cheol O., Chung, Chin Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Cell Cycle Proteins - chemistry Chlorocebus aethiops Co-Repressor Proteins COS Cells Cullin Proteins - chemistry HeLa Cells Humans Molecular Chaperones Nuclear Proteins - metabolism Nuclear Proteins - physiology Proteasome Endopeptidase Complex - metabolism Protein Structure, Tertiary Repressor Proteins - physiology Tumor Suppressor Protein p53 - metabolism Ubiquitin - chemistry Ubiquitin-Protein Ligases - chemistry
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