Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone

The aim of the study was to investigate apoptosis as a growth regulatory mechanism of gestagen in endometrial precancers and to compare differences in the apoptotic cascade after high and low dose gestagen regimens. Pre- and post-treatment paraffin-embedded endometrial hyperplasia specimens from wom...

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Veröffentlicht in:	Gynecologic oncology 2005-06, Vol.97 (3), p.740-750
Hauptverfasser:	Vereide, Anne Beate, Kaino, Turid, Sager, Georg, Ørbo, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein Biopsy Dose-Response Relationship, Drug Endometrial Hyperplasia - drug therapy Endometrial Hyperplasia - metabolism Endometrial Hyperplasia - pathology Endometrial Neoplasms - pathology Female Humans Immunohistochemistry Intrauterine Devices Levonorgestrel - administration & dosage Medroxyprogesterone - administration & dosage Middle Aged Precancerous Conditions - drug therapy Precancerous Conditions - metabolism Precancerous Conditions - pathology Progestins - administration & dosage Proto-Oncogene Proteins c-bcl-2 - biosynthesis
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