Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, significantly increased in islets of animal models of Type 2 diabe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-07, Vol.332 (4), p.927-933
Hauptverfasser:	Nakayama, Mieko, Inoguchi, Toyoshi, Sonta, Toshiyo, Maeda, Yasutaka, Sasaki, Shuji, Sawada, Fumi, Tsubouchi, Hirotaka, Sonoda, Noriyuki, Kobayashi, Kunihisa, Sumimoto, Hideki, Nawata, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aldehydes - pharmacology Angiotensin II Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensins - metabolism Animals Body Weight Deoxyguanosine - analogs & derivatives Deoxyguanosine - pharmacology Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Insulin - metabolism Islets of Langerhans - enzymology Islets of Langerhans - metabolism Membrane Glycoproteins - metabolism Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL NAD(P)H oxidase NADPH Oxidase 2 NADPH Oxidases - biosynthesis NADPH Oxidases - metabolism Oxidative Stress Phosphoproteins - metabolism Rats Rats, Inbred OLETF Rats, Long-Evans Tetrazoles - pharmacology Time Factors Type 2 diabetes Valine - analogs & derivatives Valine - pharmacology Valsartan β-cell
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