Universal initiator nucleotides for the enzymatic synthesis of 5′-amino- and 5′-thiol-modified RNA

We report the chemical synthesis of 5′-amino- and 5′-thiol-hexaethylene glycol guanosine nucleotides and their enzymatic incorporation into RNA, followed by chemical modifications at their nucleophilic ends. By using two similar routes, the conjugates of guanosine-5′-monophosphate and hexaethylene g...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-06, Vol.344 (3), p.887-892
Hauptverfasser:	Schlatterer, Jörg C., Jäschke, Andres
Format:	Artikel
Sprache:	eng
Schlagworte:	Codon, Initiator Conjugation DNA-Directed RNA Polymerases - chemistry In vitro selection Nucleotides - chemistry Ribozymes RNA - chemistry RNA, Catalytic - chemistry Sulfhydryl Compounds - chemistry Transcription Viral Proteins - chemistry
Online-Zugang:	Volltext
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