A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis
Background Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalize...
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| Veröffentlicht in: | International journal of dermatology 2006-04, Vol.45 (4), p.352-356 |
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| container_title | International journal of dermatology |
| container_volume | 45 |
| creator | Paslin, David Wertz, Philip |
| description | Background Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalizes ceramide levels.
Methods Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment.
Results Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal.
Conclusion These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti‐inflammatory actions rather than to any restorative effect on stratum corneum ceramides. |
| doi_str_mv | 10.1111/j.1365-4632.2006.02430.x |
| format | Article |
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Methods Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment.
Results Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal.
Conclusion These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti‐inflammatory actions rather than to any restorative effect on stratum corneum ceramides.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2006.02430.x</identifier><identifier>PMID: 16650156</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Allergic diseases ; Biological and medical sciences ; Ceramides - metabolism ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - metabolism ; Dermatology ; Female ; Humans ; Immunopathology ; Immunosuppressive Agents - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Ointments ; Pilot Projects ; Reference Values ; Skin - metabolism ; Skin allergic diseases. Stinging insect allergies ; Tacrolimus - therapeutic use</subject><ispartof>International journal of dermatology, 2006-04, Vol.45 (4), p.352-356</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Apr 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4620-6d62da77758f89231eeba59e2cfd909f27bad3abf135e68c2379b43e38d9f2f73</citedby><cites>FETCH-LOGICAL-c4620-6d62da77758f89231eeba59e2cfd909f27bad3abf135e68c2379b43e38d9f2f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4632.2006.02430.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4632.2006.02430.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17664964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16650156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paslin, David</creatorcontrib><creatorcontrib>Wertz, Philip</creatorcontrib><title>A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalizes ceramide levels.
Methods Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment.
Results Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal.
Conclusion These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti‐inflammatory actions rather than to any restorative effect on stratum corneum ceramides.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Ceramides - metabolism</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - metabolism</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ointments</subject><subject>Pilot Projects</subject><subject>Reference Values</subject><subject>Skin - metabolism</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Tacrolimus - therapeutic use</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1rFDEUhoModlv9CxIEvZsxHzPJ5MKLUm2tFBVUBG9CJnNCs87HmmTaXX-9me7SglcGwklynvfkcF6EMCUlzevNuqRc1EUlOCsZIaIkrOKk3D5Cq_vEY7QihNJCkVodoeMY1_nKGa2eoiMqRE1oLVbozymOae52OE24gwRh8CPgdA0YnAOb8ORwMjZMvR_miKcRWwhm8B3gHm6gj9iPd3hMwaR5wHYKI-SYdRuTPIwp4lufrrFJ08bb_EkY8nvy8Rl64kwf4fkhnqDv5--_nX0orj5fXJ6dXhW2EowUohOsM1LKunGNYpwCtKZWwKzrFFGOydZ03LSO8hpEYxmXqq048KbLSSf5CXq9r7sJ0-8ZYtKDjxb63owwzVELqajKO4Mv_wHX0xzG3JtmjDUNkw3PULOH8kxiDOD0JvjBhJ2mRC_m6LVePNCLB3oxR9-Zo7dZ-uJQf24H6B6EBzcy8OoAmGhN74IZrY8PnBSiUqLK3Ns9d-t72P13A_ry47vllPXFXu9jgu293oRfeRhc1vrHpwt9XosvVVN91T_5X4EZupQ</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Paslin, David</creator><creator>Wertz, Philip</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis</title><author>Paslin, David ; Wertz, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4620-6d62da77758f89231eeba59e2cfd909f27bad3abf135e68c2379b43e38d9f2f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergic diseases</topic><topic>Biological and medical sciences</topic><topic>Ceramides - metabolism</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - metabolism</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ointments</topic><topic>Pilot Projects</topic><topic>Reference Values</topic><topic>Skin - metabolism</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Tacrolimus - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paslin, David</creatorcontrib><creatorcontrib>Wertz, Philip</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paslin, David</au><au>Wertz, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2006-04</date><risdate>2006</risdate><volume>45</volume><issue>4</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background Atopic dermatitis (AD) is characterized both by inflammation and by abnormally low ceramide levels in the stratum corneum. Tacrolimus, effective in the treatment of AD, inhibits transcription and release of inflammatory cytokines operative in AD, but it is unknown if tacrolimus normalizes ceramide levels.
Methods Stratum corneum ceramides of seven subjects with lesional AD were measured before and after treatment with tacrolimus ointment.
Results Treatment with tacrolimus ointment did not increase the ceramide fractions toward or to normal.
Conclusion These findings suggest that tacrolimus ointment is effective in the treatment of atopic dermatitis due to its anti‐inflammatory actions rather than to any restorative effect on stratum corneum ceramides.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16650156</pmid><doi>10.1111/j.1365-4632.2006.02430.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2006-04, Vol.45 (4), p.352-356 |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adolescent Adult Allergic diseases Biological and medical sciences Ceramides - metabolism Dermatitis, Atopic - drug therapy Dermatitis, Atopic - metabolism Dermatology Female Humans Immunopathology Immunosuppressive Agents - therapeutic use Male Medical sciences Middle Aged Ointments Pilot Projects Reference Values Skin - metabolism Skin allergic diseases. Stinging insect allergies Tacrolimus - therapeutic use |
| title | A study to determine the effect of tacrolimus on ceramide levels in the stratum corneum of patients with atopic dermatitis |
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