CD36 Is Not Involved in Scavenger Receptor-Mediated Endocytic Uptake of Glycolaldehyde- and Methylglyoxal-Modified Proteins by Liver Endothelial Cells

Circulating proteins modified by advanced glycation end-products (AGE) are mainly taken up by liver endothelial cells (LECs) via scavenger receptor-mediated endocytosis. Endocytic uptake of chemically modified proteins by macrophages and macrophage-derived cells is mediated by class A scavenger rece...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2005-05, Vol.137 (5), p.607-616
Hauptverfasser:	Nakajou, Keisuke, Horiuchi, Seikoh, Sakai, Masakazu, Hirata, Kenshiro, Tanaka, Makiko, Takeya, Motohiro, Kai, Toshiya, Otagiri, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Ac-LDL Acetaldehyde - analogs & derivatives Acetaldehyde - chemistry acetylated low-density lipoprotein advanced glycation end-products AGE Animals Antibodies, Monoclonal CD36 CD36 Antigens - immunology CD36 Antigens - physiology class A scavenger receptor Endocytosis Endothelial Cells - metabolism Glycation End Products, Advanced - metabolism glycolaldehyde intermediate aldehydes LDL LEC Liver - metabolism liver endothelial cell liver endothelial cells low-density lipoprotein Male methylglyoxal Mice Mice, Knockout Oleic Acid - metabolism Ox-LDL oxidized low-density lipoprotein Pyruvaldehyde - chemistry Rats Receptors, Immunologic - physiology Receptors, Scavenger Scavenger Receptors, Class A Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism SR-A
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