Potential Role for Human Cytochrome P450 3A4 in Estradiol Homeostasis

Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed i...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2005-07, Vol.146 (7), p.2911-2919
Hauptverfasser:	Yu, Ai-Ming, Fukamachi, Katsumi, Krausz, Kristopher W, Cheung, Connie, Gonzalez, Frank J
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Aging - metabolism Alveoli Animals Aryl Hydrocarbon Hydroxylases - metabolism Beverages Biological and medical sciences Breastfeeding & lactation Casein Caseins - genetics CYP3A4 gene Cytochrome Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P-450 Enzyme System - physiology Cytochrome P450 Cytochromes P450 Dietary supplements Enzymatic activity Estradiol - metabolism Female Females Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Homeostasis Homeostasis - physiology Humans Intestine Lactation Lactation - genetics Liver - metabolism Male Mammary gland Mammary glands Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mice Mice, Transgenic Midazolam Milk Milk Proteins - genetics Oxidoreductases, N-Demethylating - metabolism Pharmacokinetics Phenotype Phenotypes Pregnenolone Pregnenolone Carbonitrile - pharmacology Sex differences Sex Factors Sex hormones Small intestine Suckling behavior Transgenes Vertebrates: endocrinology Whey acidic protein
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