Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck)

Lipoic acid is an antioxidant that suppresses and treats a model of multiple sclerosis, experimental autoimmune encephalomyelitis. We now demonstrate that treatment of human PBMC and T cell lines with LA downmodulated CD4 expression in a concentration-dependent manner. LA treatment of Con A stimulat...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-06, Vol.344 (3), p.963-971
Hauptverfasser:	Marracci, Gail H, Marquardt, Whitney E, Strehlow, Adrienne, McKeon, Gabriel P, Gross, Jonathan, Buck, David C, Kozell, Laura B, Bourdette, Dennis N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - administration & dosage CD4 Antigens - metabolism Cells, Cultured Dose-Response Relationship, Drug Down-Regulation - drug effects Down-Regulation - physiology Humans Jurkat Cells Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Protein Binding T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thioctic Acid - administration & dosage
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