Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer
Summary Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer. Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males,...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2005-06, Vol.21 (s2), p.73-78 |
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| creator | Kamada, T. Hata, J. Kusunoki, H. Kido, S. Hamada, H. Aoki, R. Nishida, T. Komoto, K. Todo, H. Sumioka, M. Tanimoto, T. Sanuki, E. Sumii, K. Ogoshi, H. Hidaka, T. Dongmei, Q. Chayama, K. Haruma, K. |
| description | Summary
Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.
Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups.
Results: The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality.
Conclusion: Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding. |
| doi_str_mv | 10.1111/j.1365-2036.2005.02478.x |
| format | Article |
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Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.
Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups.
Results: The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality.
Conclusion: Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2005.02478.x</identifier><identifier>PMID: 15943851</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antacids - therapeutic use ; Anti-Ulcer Agents - administration & dosage ; Blood Transfusion ; Endoscopy, Gastrointestinal ; Famotidine - administration & dosage ; Female ; Hemostasis, Endoscopic ; Humans ; Infusions, Intravenous ; Length of Stay ; Male ; Middle Aged ; Omeprazole - administration & dosage ; Peptic Ulcer Hemorrhage - prevention & control ; Peptic Ulcer Hemorrhage - surgery ; Secondary Prevention ; Treatment Outcome</subject><ispartof>Alimentary pharmacology & therapeutics, 2005-06, Vol.21 (s2), p.73-78</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4838-4c573906373d4c08e1f284bd3b97a0026ce56d2cd2a731d3ce2704faa77f0d193</citedby><cites>FETCH-LOGICAL-c4838-4c573906373d4c08e1f284bd3b97a0026ce56d2cd2a731d3ce2704faa77f0d193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2005.02478.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2005.02478.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15943851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamada, T.</creatorcontrib><creatorcontrib>Hata, J.</creatorcontrib><creatorcontrib>Kusunoki, H.</creatorcontrib><creatorcontrib>Kido, S.</creatorcontrib><creatorcontrib>Hamada, H.</creatorcontrib><creatorcontrib>Aoki, R.</creatorcontrib><creatorcontrib>Nishida, T.</creatorcontrib><creatorcontrib>Komoto, K.</creatorcontrib><creatorcontrib>Todo, H.</creatorcontrib><creatorcontrib>Sumioka, M.</creatorcontrib><creatorcontrib>Tanimoto, T.</creatorcontrib><creatorcontrib>Sanuki, E.</creatorcontrib><creatorcontrib>Sumii, K.</creatorcontrib><creatorcontrib>Ogoshi, H.</creatorcontrib><creatorcontrib>Hidaka, T.</creatorcontrib><creatorcontrib>Dongmei, Q.</creatorcontrib><creatorcontrib>Chayama, K.</creatorcontrib><creatorcontrib>Haruma, K.</creatorcontrib><title>Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.
Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups.
Results: The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality.
Conclusion: Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antacids - therapeutic use</subject><subject>Anti-Ulcer Agents - administration & dosage</subject><subject>Blood Transfusion</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Famotidine - administration & dosage</subject><subject>Female</subject><subject>Hemostasis, Endoscopic</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Omeprazole - administration & dosage</subject><subject>Peptic Ulcer Hemorrhage - prevention & control</subject><subject>Peptic Ulcer Hemorrhage - surgery</subject><subject>Secondary Prevention</subject><subject>Treatment Outcome</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkDtPwzAYRS0EoqXwF5AntgQ_ktgZGKqKl1QJhjJbjv0ZpcoLOxHtvyehVVnxYsvfudfyQQhTEtNx3W9jyrM0YoRnMSMkjQlLhIx3Z2h-GpyjOWFZHjFJ-QxdhbAlhGSCsEs0o2mecJnSOSofnQPT49Zhp-u2L23ZAG4b7MEM3kPT46ICGG8_sXY9eBwGYyAEN1QYGtsG03alwb0H3dcTPjadEh10_TgcKgP-Gl04XQW4Oe4L9PH0uFm9ROu359fVch2ZRHIZJSYVPCcZF9wmhkigjsmksLzIhSbjjwykmWXGMi04tdwAEyRxWgvhiKU5X6C7Q2_n268BQq_qMhioKt1AOwSViZxKztkIygNofBuCB6c6X9ba7xUlatKstmqyqSabatKsfjWr3Ri9Pb4xFDXYv-DR6wg8HIDvsoL9v4vV8n0znfgPv0GM7w</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Kamada, T.</creator><creator>Hata, J.</creator><creator>Kusunoki, H.</creator><creator>Kido, S.</creator><creator>Hamada, H.</creator><creator>Aoki, R.</creator><creator>Nishida, T.</creator><creator>Komoto, K.</creator><creator>Todo, H.</creator><creator>Sumioka, M.</creator><creator>Tanimoto, T.</creator><creator>Sanuki, E.</creator><creator>Sumii, K.</creator><creator>Ogoshi, H.</creator><creator>Hidaka, T.</creator><creator>Dongmei, Q.</creator><creator>Chayama, K.</creator><creator>Haruma, K.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer</title><author>Kamada, T. ; Hata, J. ; Kusunoki, H. ; Kido, S. ; Hamada, H. ; Aoki, R. ; Nishida, T. ; Komoto, K. ; Todo, H. ; Sumioka, M. ; Tanimoto, T. ; Sanuki, E. ; Sumii, K. ; Ogoshi, H. ; Hidaka, T. ; Dongmei, Q. ; Chayama, K. ; Haruma, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4838-4c573906373d4c08e1f284bd3b97a0026ce56d2cd2a731d3ce2704faa77f0d193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antacids - therapeutic use</topic><topic>Anti-Ulcer Agents - administration & dosage</topic><topic>Blood Transfusion</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Famotidine - administration & dosage</topic><topic>Female</topic><topic>Hemostasis, Endoscopic</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Omeprazole - administration & dosage</topic><topic>Peptic Ulcer Hemorrhage - prevention & control</topic><topic>Peptic Ulcer Hemorrhage - surgery</topic><topic>Secondary Prevention</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamada, T.</creatorcontrib><creatorcontrib>Hata, J.</creatorcontrib><creatorcontrib>Kusunoki, H.</creatorcontrib><creatorcontrib>Kido, S.</creatorcontrib><creatorcontrib>Hamada, H.</creatorcontrib><creatorcontrib>Aoki, R.</creatorcontrib><creatorcontrib>Nishida, T.</creatorcontrib><creatorcontrib>Komoto, K.</creatorcontrib><creatorcontrib>Todo, H.</creatorcontrib><creatorcontrib>Sumioka, M.</creatorcontrib><creatorcontrib>Tanimoto, T.</creatorcontrib><creatorcontrib>Sanuki, E.</creatorcontrib><creatorcontrib>Sumii, K.</creatorcontrib><creatorcontrib>Ogoshi, H.</creatorcontrib><creatorcontrib>Hidaka, T.</creatorcontrib><creatorcontrib>Dongmei, Q.</creatorcontrib><creatorcontrib>Chayama, K.</creatorcontrib><creatorcontrib>Haruma, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamada, T.</au><au>Hata, J.</au><au>Kusunoki, H.</au><au>Kido, S.</au><au>Hamada, H.</au><au>Aoki, R.</au><au>Nishida, T.</au><au>Komoto, K.</au><au>Todo, H.</au><au>Sumioka, M.</au><au>Tanimoto, T.</au><au>Sanuki, E.</au><au>Sumii, K.</au><au>Ogoshi, H.</au><au>Hidaka, T.</au><au>Dongmei, Q.</au><au>Chayama, K.</au><au>Haruma, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2005-06</date><risdate>2005</risdate><volume>21</volume><issue>s2</issue><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Aim: We investigated the effect of acid suppression therapy on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer.
Methods: A total of 400 patients with bleeding peptic ulcer received either intravenous infusion of famotidine (40 mg/day) (n = 207, 163 males, 44 females, mean age 61.5 years) or drip infusion of omeprazole (40 mg/day; n = 193, 134 males, 59 females, mean age 59.8 years) after successful endoscopic treatment. The fasting duration, hospital stay, volume of transfused blood, incidence of rebleeding and mortality were compared between the two groups.
Results: The incidence of rebleeding did not differ significantly between the famotidine group (9%) and the omeprazole group (8%). The mean hospital stay was significantly shorter in the omeprazole group (18.4 days) than in the famotidine group (21.5 days, P = 0.009). However, there was no statistically significant difference in fasting duration, volume of transfused blood or mortality.
Conclusion: Our findings indicate that intravenous infusion of famotidine after successful endoscopic treatment is equivalent to drip infusion of omeprazole for prevention of recurrent bleeding.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15943851</pmid><doi>10.1111/j.1365-2036.2005.02478.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adolescent Adult Aged Aged, 80 and over Antacids - therapeutic use Anti-Ulcer Agents - administration & dosage Blood Transfusion Endoscopy, Gastrointestinal Famotidine - administration & dosage Female Hemostasis, Endoscopic Humans Infusions, Intravenous Length of Stay Male Middle Aged Omeprazole - administration & dosage Peptic Ulcer Hemorrhage - prevention & control Peptic Ulcer Hemorrhage - surgery Secondary Prevention Treatment Outcome |
| title | Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer |
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